Assessing Quality of Life in Clinical Trials
Methods and practice
2nd Edition
Published on 10. March 2005
Book
Hardback
488 pages
978-0-19-852769-5 (ISBN)
Description
Quality of Life Assessment has progressed considerably since the publication of the first highly acclaimed edition of this book in 1998. Quality of life has now become an indispensable outcome measure in many randomised clinical trials and other studies. Thus, it is timely to provide not just an update, but a completely new edition that reviews the current state of art and also discusses topical issues including areas where active research is in progress.
The first section discusses the development and evaluation of generic and disease-targeted questionnaires. Having decided the items to be included the thrust of the next section covers how to convert these into usable forms. Section 3 addressing analysis and the methods of analysing studies with missing data is followed by chapters on interpretation of results and exploring the role of single-item questions. The final section of the book looks beyond the individual clinical trial and how we can use clinical trial and other data to make macro-decisions.
A strong international team of experts cover a wide range of topics, emphasizing new and innovative approaches that are of practical and clinical importance, reviewing the current state of the art and illustrating the benefits and potential of health related quality of life assessment in clinical trials.
The first section discusses the development and evaluation of generic and disease-targeted questionnaires. Having decided the items to be included the thrust of the next section covers how to convert these into usable forms. Section 3 addressing analysis and the methods of analysing studies with missing data is followed by chapters on interpretation of results and exploring the role of single-item questions. The final section of the book looks beyond the individual clinical trial and how we can use clinical trial and other data to make macro-decisions.
A strong international team of experts cover a wide range of topics, emphasizing new and innovative approaches that are of practical and clinical importance, reviewing the current state of the art and illustrating the benefits and potential of health related quality of life assessment in clinical trials.
Reviews / Votes
This book is clearly written, resource-rich, and eloquently blends both traditional and innovative approaches to measuring HRQoL in clinical trials... Fayers and Hays' new edition encapsulates the essential and highly regarded notion of patient-centered care and will prove to be an outstanding addition to any clinical researcher's library. * Quality of Life Research, Vol 15 * This excellently presented book achieves its aims of being an introduction to QoL, and its assessment, analysis, and interpretation. * International Journal of Epidemiology, Vol 34, No. 6 * This book represents a comprehensive overview of the field with contributions from 31 authors, in a collection of 24 chapters. The objective of this book is to provide a thorough review of the current state of the art methodology. The objective is whole-heartedly achieved through its six sections. * Journal of Biopharmaceutical Statistics *More details
Edition
2nd Revised edition
Language
English
Place of publication
Oxford
United Kingdom
Target group
Professional and scholarly
Edition type
Revised edition
Illustrations
numerous tables
Dimensions
Height: 260 mm
Width: 183 mm
Thickness: 30 mm
Weight
1093 gr
ISBN-13
978-0-19-852769-5 (9780198527695)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Previous edition
Book
02/1998
Oxford University Press
€61.29
Article exhausted; check for reprint
Persons
Content
Preface ; 1. DEVELOPING AND EVALUATING QUESTIONNAIRES ; 1.1 Generic versus disease-targeted instruments ; 1.2 Developing questionnaires ; 1.3 Reliability and validity, including responsiveness ; 1.4 Evaluating multi-item scales ; 1.5 Rasch models & IRT ; 2. ADAPTING AND USING QUESTIONNAIRES ; 2.1 Translating and evaluating questionnaires - cultural issues ; 2.2 CAT and item banking ; 2.3 Developing a questionnaire using IRT - a case study of fatigue ; 2.4 Proxy assessments and context effects ; 3. ANALYSIS ; 3.1 Analysing longitudinal studies of QOL ; 3.2 Preventing missing data ; 3.3 Analysing studies with missing data ; 3.4 Differential item functioning (DIF) for analysing cultural differences ; 3.5 Reporting analyses from clinical trials ; 4. INTERPRETING QOL IN INDIVIDUALS AND GROUPS ; 4.1 Individualised QoL ; 4.2 Meaningful differences ; 4.3 Health-related QoL outcomes in clinical trials ; 4.4 Response shift ; 4.5 Individual patient monitoring ; 5. MEASURES FOR CLINICAL TRIALS ; 5.1 Self-rated health ; 5.2 Generic adult health status measures ; 5.3 Measurement of HRQL in child/adolescent clinical trials ; 5.4 Developing disease-targeted measures for neurolgic conditions ; 6. BEYOND CLINICAL TRIALS ; 6.1 Values and valuation ; 6.2 Preference-based measures ; 6.3 Discrete choice experiments ; 6.4 Combining clinical trials - meta analysis