
Fibroblast Growth Factor 23
Elsevier (Publisher)
Published on 9. April 2021
Book
Paperback/Softback
376 pages
978-0-12-818036-5 (ISBN)
Description
Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23.
Reviews / Votes
"...reviews the important role of fibroblast growth factor 23 (FGF23) and its association with human disease.... to provide an overview of the impact FGF23 has on different systems and offer a single resource for researchers to understand the larger scope of its utility.... [T]he first textbook fully dedicated to FGF23,.... it is critical to understand this protein as we learn to target these disease pathways...in many fields, including nephrology, bone metabolism, and cardiology. [A]uthored by established investigators studying FGF23 and Klotho who have shaped this line of research, as well as newer investigators who have expanded the field with novel insights.... [E]asy to read,... a unique and important book. As a provider in nephrology and bone metabolism, I have already referenced it on several occasions in review of patient cases." -- (c)Doody's Review Service, 2023, Jon Webb, MD (University of Kentucky College of Medicine)More details
Language
English
Place of publication
United States
Target group
Professional and scholarly
Biomedical researchers and research clinicians in the field researching FGF23; basic scientists in physiology, biochemistry and genetics, clinicians such as nephrologists, bone and mineral researchers and endocrinologists
Illustrations
Approx. 100 illustrations (75 in full color)
Dimensions
Height: 276 mm
Width: 216 mm
Weight
1110 gr
ISBN-13
978-0-12-818036-5 (9780128180365)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions

Christian Faul | Kenneth White | Orlando Gutierrez
Fibroblast Growth Factor 23
E-Book
04/2021
Elsevier
€175.00
Available for download
Persons
Dr. Faul earned his PhD title at the Albert Einstein College of Medicine in the Bronx in 2005, and conducted his postdoctoral research training at the Mount Sinai School of Medicine in New York City. He currently is an Associate Professor in the Division of Nephrology within the Department of Medicine and in the Department of Cell, Developmental and Integrative Biology (CDIB) at UAB.) He is also a member of the Comprehensive Diabetes Center and Section of Cardio-Renal Physiology and Medicine. He focuses on circulating fibroblast growth factors and their pathological effects on the heart in the context of diabetes and chronic kidney disease. In collaborations with pharma industry, Dr. Faul analyzes beneficial cardiac effects of pharmacological blockers for fibroblast growth factor receptors in animal models with diabetes and kidney injury. Dr. Faul received research funding from the American Diabetes Association (ADA), the American Society of Nephrology (ASN), and American Heart Association (AHA), and the NephCure Foundation, as well as support from pharma industry. Dr. White studied the molecular genetics of metabolic bone diseases during an NIH-sponsored postdoctoral fellowship at the Indiana University School of Medicine (IUSM). He played an instrumental role in discovering the novel hormone FGF23 during this time, and since then his laboratory has been funded to study FGF23 and its co-receptor Klotho. Within the University, he is Director of the MMGE Division of Molecular Genetics and Gene Therapy and currently a member of the Indiana Center for Musculoskeletal Health (ICMH). Dr. Gutierrez is the Hilda B. Anderson Endowed Chair in Nephrology, Professor of Medicine and Epidemiology, Associate Director of the Division of Nephrology, and Deputy Director of the Center for Clinical and Translational Science at the University of Alabama at Birmingham (UAB). Dr. Gutierrez's research is focused on understanding pathophysiological mechanisms underlying disorders of phosphorus and vitamin D metabolism in health and in individuals with kidney disease. He has a special interest in delineating environmental and/or behavioral factors that may modulate these associations, particularly those related to health disparities, poverty and nutrition. To this end, his group conducts epidemiologic and patient-oriented studies investigating the impact of disturbances in phosphorus metabolism on kidney and cardiovascular health. He is funded by grants from the National Institutes of Health, the American Heart Association, and industry.
Editor
Associate Professor of Medicine, Department of Medicine, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL, USA
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
Hilda B. Anderson Endowed Chair in Nephrology, Professor of Medicine and Epidemiology, Associate Director of the Division of Nephrology, and Deputy Director of the Center for Clinical and Translational Science, University of Alabama at Birmingham, USA
Content
1. The discovery of FGF23 - a historic view: genetic disorders of hypo- and hyperphosphatemia
2. FGF23 - an established master regulator of phosphate metabolism
3. FGF23 - more than a phosphaturic hormone
4. The regulation of FGF23 production in bone and outside of bone
5. Klotho-dependent actions of FGF23 - targets, signal transduction and cellular effects
6. Klotho-independent actions of FGF23 - targets, signal transduction and cellular effects
7. The experimental detection of FGF23 responsiveness and effects
8. FGF23 and bone disease
9. FGF23 and kidney disease
10. FGF23 and heart and vascular disease
11. FGF23 and inflammation, anemia, and iron
12. FGF23 and infectious diseases
13. FGF23 and lung disease
14. FGF23 and neuro-cognitive disorders
15. FGF23 as a drug target
16. FGF23 - resolved issues, remaining controversies and future questions - a clinician's perspective
17. Klotho - the discovery of the FGF23 co-receptor
18. Klotho - an FGF23-independent hormone
19. Klotho and aging phenotypes
20. ?Klotho gene and protein measurements in humans and their role as a clinical biomarker of disease
21. Structural Basis of FGF23 Hormone Signaling
22. Klotho - open questions, controversies and future perspectives
23. The crosstalk between phosphate, FGF23 and klotho in the regulation of tissue homeostasis in health and disease
2. FGF23 - an established master regulator of phosphate metabolism
3. FGF23 - more than a phosphaturic hormone
4. The regulation of FGF23 production in bone and outside of bone
5. Klotho-dependent actions of FGF23 - targets, signal transduction and cellular effects
6. Klotho-independent actions of FGF23 - targets, signal transduction and cellular effects
7. The experimental detection of FGF23 responsiveness and effects
8. FGF23 and bone disease
9. FGF23 and kidney disease
10. FGF23 and heart and vascular disease
11. FGF23 and inflammation, anemia, and iron
12. FGF23 and infectious diseases
13. FGF23 and lung disease
14. FGF23 and neuro-cognitive disorders
15. FGF23 as a drug target
16. FGF23 - resolved issues, remaining controversies and future questions - a clinician's perspective
17. Klotho - the discovery of the FGF23 co-receptor
18. Klotho - an FGF23-independent hormone
19. Klotho and aging phenotypes
20. ?Klotho gene and protein measurements in humans and their role as a clinical biomarker of disease
21. Structural Basis of FGF23 Hormone Signaling
22. Klotho - open questions, controversies and future perspectives
23. The crosstalk between phosphate, FGF23 and klotho in the regulation of tissue homeostasis in health and disease