Immunogenomics and Human Disease
1st Edition
Published on 2. December 2005
Book
Hardback
548 pages
978-0-470-01530-8 (ISBN)
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Description
One of the major features that distinguishes vertebrates from invertebrates is the presence of a complex immune system. Over millions of years, many novel immune genes and gene families have emerged and their products form sophisticated pathways conferring protection against most pathogens. The Human Genome Project revealed that the immunoglobulin gene superfamily was one of the largest in the genome, containing more than 2% of all known human genes. High-throughput technologies for the study of DNA, mRNA and proteins, such as microarrays and real-time gene amplification technologies, as well as biobank facilities, are enabling the investigation of these genes and pathways in ever more detail. The parallel development of databases and bioinformatics tools to store and interpret this information will also contribute to greater understanding of the function of the immune system.
Genomics is finally changing from an academic discipline to one with real clinical relevance. The study of immune regulation in response to pathogen invasion, to the presence of malignant or allogeneic tissue and, in some cases, to normal autologous tissue requires techniques that study the behaviour of whole systems in parallel. A genome-wide, systems biology approach is needed to understand the genetic and environmental factors that regulate the healthy immune system and its response to pathogens as well as to malignant cells arising within the body. It will also facilitate determining what goes wrong when the immune system attacks normal host cells, as in autoimmune diseases such as Type 1 diabetes.
Finally, greater knowledge of the immune system will enable us to use it to promote health and cure disease, through vaccine development - targeting both pathogens and tumour cells - and by manipulation of cellular and humoral defences.
This book provides an overview of key conceptual and molecular technologies being deployed in immunogenomics, followed by detailed evaluations of the impact of genomics and systems biology on important areas such as cancer immunology, autoimmunity, allergy and the response to infection. It will be of interest to all those working in immunology, as well as to bioinformaticians and specialists such as oncologists and microbiologists.
Reviews / Votes
"...the first book attempting to review the current bioinformatics literature as it specifically applies to the immune system...should prove valuable to researchers interested in immunogenetics." (Doody's Health Services)More details
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Person
Professor Falus is Chairman of the Department of Genetics, Cell and Immunobiology at Semmelweis Medical University in Budapest and a Member of the Hungarian Academy of Sciences. He has written and edited several books on immunology, particularly histamine.
Content
Preface.
List of contributors.
1. Genotyping methods and disease gene identification (Ramón Kucharzak and Ivo Glynne Gut).
2. Glycomics and the Sugar Code: Primer to their Structural Basis and Functionality (Hans-Joachim Gabius).
3. Proteomics in Clinical Research: Perspectives and Expectations (Ivan Lefkovits, Thomas Grussenmeyer, Peter Matt, Martin Grapow, Michael Lefkovits and Hans-Reinhard Zerkowski).
4. Chemical genomics: bridging the gap between novel targets and small molecule drug candidates. Contribution to immunology (György Dormán, Takenori Tomohiro, Yasumaru Hatanaka and Ferenc Darvas).
5. Genomic and proteomic analysis of activated human monocytes (Ameesha Batheja, George Ho, Xiaoyao Xiao, Xiwei Wang and David Uhlinger).
6. Bioinformatics as a problem of knowlege representation: applications to some aspects of immunoregulation (Sándor Pongor and András Falus).
7. Immune responsiveness of human tumours (Ena Wang and Francesco M. Marincola).
8. Chemokines regulate leukocyte trafficking and organ-specific metastasis (Andor Pivarcsi, Anja Mueller and Bernhard Homey).
9. Towards a unified approach to new target discovery in breast cancer: combining the power of genomics, proteomics and immunology(Laszlo G. Radvanyi, Bryan Hennessy, Kurt Gish, Gordon Mills and Neil Berinstein).
10. Genomics and Functional Differences of Dendritic Cell Subsets (Peter Gogolak and Eva Rajnavölgyi).
11. Systemic lupus erythematosus: new ideas for diagnosis and treatment (Sandeep Krishnan and George C. Tsokos).
12. Immunogenetics of experimentally induced arthritis (Tibor T. Glant and Vyacheslav A. Adarichev).
13. Synovial activation in rheumatoid arthiritis (Lars C. Huber, Renate E. Gay and Steffen Gay).
14. T cell epitope hierarchy in experimental autoimmune models (Edit Buzas).
15. Gene-gene interactions in immunology as exemplified by studies on autoantibodies against 60 kDa heat-shock protein (Zoltán Prohászka).
16. Histamine genomics and metabolomics (Andras Falus, Hargita Hegyesi, Susan Darvas, Zoltan Pos and Peter Igaz).
17. The histamine H_4 receptor: drug discovery in the post-genomic era(Niall O'Donnell, Paul J. Dunford and Robin L. Thurmond).
18. Application of microarray technology to bronchial asthma (Kenji Izuhara, Kazuhiko Arima, Sachiko Kanaji, Kiyonari Masumoto and Taisuke Kanaji).
19. Genomic investigation of asthma in human and animal models (Csaba Szalai).
20. Primary immunodeficiencies: genotype-phenotype correlations (Mauno Vihinen and Anne Durandy).
21. Transcriptional profiling of dentritic cells in response to pathogens (Maria Foti, Francesca Granucci, Mattia Pelizzola, Norman Pavelka, Ottavio Beretta, Caterina Vizzardelli, Matteo Urbano, Ivan Zanoni, Giusy Capuano, Francesca Mingozzi and Paola Ricciardi-Castagnoli).
22. Parallel biology: a systematic approach to drug target and biomarker discovery in chronic obstructive pulmonary disease (Laszlo Takacs).
23. Mycobacterial granulomas: a genomic approach (Laura H. Hogan, Dominic O. Co and Matyas Sandor).
Index.