Twentieth Century Mouse Genetics
A Historical and Scientific Review
Published on 6. September 2021
Book
Paperback/Softback
344 pages
978-0-12-824016-8 (ISBN)
Description
Twentieth Century Mouse Genetics: A Historical and Scientific Review provides a comprehensive examination of key advances in mouse genetics throughout the 20th century. Here Dr. Robert P. Erickson, a leader in the field, identifies the contributions of historic mouse genetics studies, and how those approaches and early discoveries are still shaping human genetics research and medical genetics today. In addition to historical overviews, the author provides researcher biographies and updates connecting historic research to ongoing advances. Past studies discussed use the T/t complex as an example and include the origins of mouse genetics, the synthesis of genetics and evolution, cytogenetics and gene mapping, population genetics and mutation research, immunogenetics, reproductive genetics, molecular cloning, X-inactivation and epigenetics, sex determination, and pharmacogenetics. Here researchers, students, and clinicians will find fresh inspiration to engage in human genetics research employing mouse models and to translate those findings to clinical practice.
Reviews / Votes
"This book will have strong appeal to a limited audience. Those interested in the history and development of mouse genetics, and of mouse genetics in the wider context of the history of genetics, will find this book an interesting read. Indeed, it stands out from other books covering similar topics by the personal experience of the author in the field. " -- (c) Doody's Review Service, 2021, Mark F. Sanders, PhD, reviewer, expert opinionMore details
Language
English
Place of publication
San Diego
United States
Publishing group
Elsevier Science Publishing Co Inc
Target group
Professional and scholarly
Active researchers and students of genetics, biochemistry, molecular biology, cellular biology, lab animal science, and pharmacology
Product notice
Paperback (trade)
Illustrations
40 illustrations; Illustrations
Dimensions
Height: 235 mm
Width: 191 mm
Thickness: 18 mm
Weight
593 gr
ISBN-13
978-0-12-824016-8 (9780128240168)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
08/2021
Academic Press
€122.00
Available for download
Person
Dr. Robert P. Erickson is the Holsclaw Family Professor Emeritus of Human Genetics and Inherited Diseases, Department of Pediatrics, University of Arizona College of Medicine. He has had a 50 year career of research in human and murine genetics, especially molecular, and patient care. He is author of over 400 scientific and medical papers and has co-authored or co-edited 5 books. He has received Guggenheim and Eleanor Roosevelt Fellowships, was made an honorary visiting fellow of Hughes Hall, University of Cambridge, and a visiting research professor at Universita Roma de la Sapienza. His public service includes being an appointee by then Governor Napolitano to the Arizona Biomedical Research Committee, membership of the Recombinant DNA Advisory Committee (RAC) of the National Institutes of Health and membership of the Scientific Board of Advisors of the International Institute of Molecular and Cellular Biology in Warsaw. He is listed in Who's Who of America.
Content
1. The origins of mouse genetics and the discovery of the T-locus
2. The evolutionary modern synthesis, t-haplotypes in the wild, and reproductive isolation
3. Linkage studies, cytogenetics, and the discovery that t-haplotypes consist of a series of inversions-an over-the-Century Project
4. Developmental genetics and recessive t-lethals
5. More population genetics with particular attention to the effects of t-allele mediated transmission ratio distortion
6. Mutation studies including those targeting the T/t-complex-a century long project
7. Immunogenetics and the failed search for t-antigens-from mid-century and continuing to it's end
8. Gametogenesis and the genetics of gametes, including t-haplotype segregation distortion
9. The cloning era and the cloning of Brachury and other T/t complex genes
10. X-inactivation, epigenetics, and imprinting, including of the T/t complex
11. Sex determination, sex differentiation, and the Y chromosome-a mostly last quarter of the century effort
12. Pharmacogenetics-a mostly last half of the century effort
Book Bibliography
2. The evolutionary modern synthesis, t-haplotypes in the wild, and reproductive isolation
3. Linkage studies, cytogenetics, and the discovery that t-haplotypes consist of a series of inversions-an over-the-Century Project
4. Developmental genetics and recessive t-lethals
5. More population genetics with particular attention to the effects of t-allele mediated transmission ratio distortion
6. Mutation studies including those targeting the T/t-complex-a century long project
7. Immunogenetics and the failed search for t-antigens-from mid-century and continuing to it's end
8. Gametogenesis and the genetics of gametes, including t-haplotype segregation distortion
9. The cloning era and the cloning of Brachury and other T/t complex genes
10. X-inactivation, epigenetics, and imprinting, including of the T/t complex
11. Sex determination, sex differentiation, and the Y chromosome-a mostly last quarter of the century effort
12. Pharmacogenetics-a mostly last half of the century effort
Book Bibliography