Current Directions in Autoimmunity / Apoptosis and Its Relevance to Autoimmunity
1st Edition
Published on 19. December 2005
Book
Hardback
210 pages
978-3-8055-8036-6 (ISBN)
Description
Over the last 15 years, apoptosis has become a dominant focus of medical research in the field of immunology. This publication discusses the three major areas of apoptosis research: extrinsic death receptor pathways, intrinsic cell death pathways and the mechanisms responsible for apoptotic cell clearance. Each section delineates the proteins and signal transduction pathways and describes genetic alterations that lead to autoimmune diseases. Although most cell death abnormalities have been associated with systemic autoimmune disorders such as lupus erythematosus and lymphoproliferative syndromes, it is evident that regulation of cell death is also pertinent to disease expression in many organ-specific diseases such as rheumatoid arthritis and glomerulonephritis.
This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of disease. It is of special interest to cell biologists, immunologists and clinicians.
This volume highlights the recent advances in the basic mechanisms of apoptosis and the application of that knowledge to understanding the impact of defective apoptosis or defective clearance of apoptotic cells on the immune function and the expression of disease. It is of special interest to cell biologists, immunologists and clinicians.
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Content
Preface: Elkon, K.B.; Extrinsic Death Receptor Pathways; Death Receptor Signaling and Its Function in the Immune System: Fas, S.C.; Fritzsching, B.; Suri-Payer, E.; Krammer, P.H.; Inherited and Acquired Death Receptor Defects in Human Autoimmune Lymphoproliferative Syndrome: Rieux-Laucat, F.; Tumor Necrosis Factor Ligand-Receptor Super-family and Arthritis: Hsu, H.-C.; Wu, Y.; Mountz, J.D.; Intrinsic Death Pathways; Mitochondria, Apoptosis and Autoimmunity: Pinkoski, M.J.; Waterhouse, N.J.; Green, D.R.; Role of Bim and other Bcl-2 Family Members in Autoimmune and Degenerative Diseases: Hughes, P.; Bouillet, P.; Strasser, A.; Mitochondria, Cell Death, and B Cell Tolerance: Deming, P.B.; Rathmell, J.C.; Apoptotic Cell Clearance; Role of Complement and Other Innate Immune Mechanisms in the Removal of Apoptotic Cells: Ogden, C.A.; Elkon, K.B.; Collectins: Opsonins for Apoptotic Cells and Regulators of Inflammation: Stuart, L.M.; Henson, P.M.; Vandivier, R.W.; MFG-E8-Dependent Clearance of Apoptotic Cells, and Autoimmunity Caused by Its Failure: Hanayama, R.; Miyasaka, K.; Nakaya, M.; Nagata, S.; Clearance of Apoptotic Cells in Human SLE: Gaipl, U.S.; Kuhn, A.; Sheriff, A.; Munoz, L.; Franz, S.; Voll, R.E.; Kalden, J.R.; Herrmann, M.; Apoptosis and Glomerulonephritis: Watson, S.; Cailhier, J.-F.; Hughes, J.; Savill, J.; Author Index; Subject Index.