Comprehensive Toxicology, Volume 9
Hepatic and Gastrointestinal Toxicology
Published on 4. August 1999
Book
Hardback
750 pages
978-0-08-042974-8 (ISBN)
Description
This volume, which is separated into two parts, presents important new information concerning mechanisms of effect and consequences of exposure of the liver and gastrointestinal tract to a wide variety of toxicants. Both sections on the liver and GI tract provide the reader with concise introductory descriptions of relevant cellular and organ anatomy, physiology, and mechanisms of toxic injury. Specific consideration is given to methods of toxin exposure and to processes that provide defence against injury. The discussions provide a broad focus but also contain details about molecular, cellular, and biochemical mechanisms.
The section on the liver (34 chapters) provides a comprehensive review of the toxic effects of a wide variety of specific compounds including volatile hydrocarbons, anesthetic agents, drugs of therapeutic value as well as of abuse, heavy metals, natural compounds etc. The section on the gastrointestinal tract (15 chapters), presenting toxicology of the esophagus, stomach, small intestine, and colon, represents the first major reference work available that provides both a broad overview of the effect of toxicants on the mucosal, motility, and immune functions of the GI tract as well as specific information about specific toxicants. The final chapter presents an overview of clinical toxicology in animals with specific focus on the liver and gastrointestinal systems.
This volume is of specific interest and use to those concerned with environmental and industrial toxicology, as well as with mechanisms of toxicant injury and clinical medicine.
The section on the liver (34 chapters) provides a comprehensive review of the toxic effects of a wide variety of specific compounds including volatile hydrocarbons, anesthetic agents, drugs of therapeutic value as well as of abuse, heavy metals, natural compounds etc. The section on the gastrointestinal tract (15 chapters), presenting toxicology of the esophagus, stomach, small intestine, and colon, represents the first major reference work available that provides both a broad overview of the effect of toxicants on the mucosal, motility, and immune functions of the GI tract as well as specific information about specific toxicants. The final chapter presents an overview of clinical toxicology in animals with specific focus on the liver and gastrointestinal systems.
This volume is of specific interest and use to those concerned with environmental and industrial toxicology, as well as with mechanisms of toxicant injury and clinical medicine.
More details
Language
English
Place of publication
London
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
Professional and scholarly
Illustrations
Illustrations (some col.)
Weight
1880 gr
ISBN-13
978-0-08-042974-8 (9780080429748)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Persons
Content
Section 1: Hepatic Toxicology. Introduction to the liver and its responses to toxicants (I.G. Sipes, R.S. McCuskey). Structure and function of hepatic parenchymal cells (E.L. Cardell, R.R. Cardell). Hepatic nonparenchymal cells: endothelial cells, Kupffer cells, fat-storing cells, and pit cells (R.S. McCuskey, E. Wisse). Cells of the liver: biliary epithelium (S.A. Levine, N.R. LaRusso). Xenobiotic metabolism by the liver (F.C. Kauffman). Evaluation of hepatotoxicity: physiological and biochemical measures of hepatic function (G. L. Plaa, H.J. Zimmerman). Pathological response to toxic injury (P. De la Motte Hall). Xenobiotic-induced inflammation and injury in the liver (D.L. Laskin). Carcinogenic responses to toxic liver injury in rodents (G.M. Williams). Antioxidant defense mechanisms (H. Jaeschke). Proteases and transcription factors: cutting edge determinants of the proliferative or apoptotic response in hepatic tissue (D. Kaplan, R.F. Novak). Hepatic defenses against toxicity: regeneration (H.M. Mehendale, K.N. Thakore, D. Chanda, A. Dalu, S. Kulkarni, P.S. Rao, R.S. Mangipudy). In vitro methods (B.G. Lake). Carbon tetrachloride (J.A. Castro, G.D. Castro). Volatile halogenated hydrocarbons (J.B. Wijeweera). Hexachlorobenzene: effects on porphyrin metabolism (M. Charbonneau). Hepatotoxicity of the fluorinated anesthetic agent (M.T. Baker). Role of Kupffer cells, endotoxin and free radicals in mediating hepatotoxicity due to alcohol (R.G. Thurman, B.U. Bradford, Y. Iimuro, K.T. Knecht, H.D. Connor, Y. Adachi, C. Wall, G.E. Arteel, J.A. Raleigh, D.T. Forman, R.P. Mason). Cocaine hepatotoxicity (R.D. Harbison, R.P. Demott). Acetaminophen (S.D. Cohen, D.J. Hoivik, E.A. Khairallah). Effects of chlorpromazine on the liver (H.J. Zimmerman). Nitrofurantoin (H.J. Zimmerman). Isoniazid (T.C. Sarich, J.M. Wright). Pesticides (E. Hodgson, S.A. Meyer). Hepatotoxicity of copper, iron, and cadmium (C.D. Klaassen, P.L. Goering). Aflatoxin toxicology (D.L. Eaton, J.T. Heinonen). Pyrrolizidine alkaloids (R.J. Huxtable). Bacterial endotoxin (K.F. Decker). &agr;-Naphthylisothiocyanate (P.E. Ganey, R.A. Roth, L.J. Dahm). Allyl alcohol (P.E. Ganey, R.A. Roth, L.J. Dahm). Bromobenzene hepatotoxicity: a paradigm of reactive electrophilic metabolites binding covalently to tissue macromolecules. Is there light at the end of the tunnel? (T.J. Monks, S.S. Lau). D-galactosamine (K. Decker). Thioacetamide (H.M. Mehendale, S. Chanda). The hepatotoxicity of Vitamin A (All-trans-Retinol) (I.G. Sipes, J.M. Sauer, D.A. Badger).
Section 2: Gastrointestinal Toxicology. Gastrointestinal system: introduction (D.L. Earnest). Anatomy (esophagus, stomach, small intestine, colon) (A.V. LeBouton). Gastrointestinal system: overview of physiology (E.D. Jacobson). The gastrointestinal tract immune system (F. Shanahan). The metabolic barrier of the gastrointestinal tract (P.B. Watkins). Pathophysiological mechanisms of gastrointestinal toxicity (T.F. Burks II). Interaction of toxicants with gastrointestinal tract microbial flora (G.L. Simon, S.L. Gorbach). Toxicants and gastrointestinal tract cellular proliferation and cancer (M.J. Wargovich). Sources of gastrointestinal tract toxins (food, industrial, and environmental chemicals, metals) (K.K. Rozman, M. Viluksela). Absorption, enterohepatic circulation and fecal excretion of toxicants (C.D. Klaassen, J.B. Watkins III). Clinical toxicity of common drugs and chemicals: esophagus (D.O. Castell). Clinical toxicity of common drugs and chemicals in humans: stomach (S. Szabo, A. Vincze). Small bowel toxicology (D.J. Bjorkman). Clinical toxicity of common drugs and chemicals: colon (D.L. Earnest). In vitro and in vivo models of gastrointestinal toxicology (R. Bird). Clinical toxicology in animals (S.B. Hooser).
Section 2: Gastrointestinal Toxicology. Gastrointestinal system: introduction (D.L. Earnest). Anatomy (esophagus, stomach, small intestine, colon) (A.V. LeBouton). Gastrointestinal system: overview of physiology (E.D. Jacobson). The gastrointestinal tract immune system (F. Shanahan). The metabolic barrier of the gastrointestinal tract (P.B. Watkins). Pathophysiological mechanisms of gastrointestinal toxicity (T.F. Burks II). Interaction of toxicants with gastrointestinal tract microbial flora (G.L. Simon, S.L. Gorbach). Toxicants and gastrointestinal tract cellular proliferation and cancer (M.J. Wargovich). Sources of gastrointestinal tract toxins (food, industrial, and environmental chemicals, metals) (K.K. Rozman, M. Viluksela). Absorption, enterohepatic circulation and fecal excretion of toxicants (C.D. Klaassen, J.B. Watkins III). Clinical toxicity of common drugs and chemicals: esophagus (D.O. Castell). Clinical toxicity of common drugs and chemicals in humans: stomach (S. Szabo, A. Vincze). Small bowel toxicology (D.J. Bjorkman). Clinical toxicity of common drugs and chemicals: colon (D.L. Earnest). In vitro and in vivo models of gastrointestinal toxicology (R. Bird). Clinical toxicology in animals (S.B. Hooser).