
Fetuin
Springer (Publisher)
Published on 18. April 2014
Book
Paperback/Softback
VIII, 180 pages
978-3-662-21900-3 (ISBN)
Description
DISCOVERY AND IDENTIFICATION OF FETUIN etuin was discovered in 1944 because of its behavior in the ultra- F 1 centrifuge. In his historical review of fetuin, Kai Pedersen, the original discoverer of the protein, wrote, "it (fetuin) was quite different from other serum proteins previously studied. It precipitated abundantly in an ammonium sulphate concentration range in which earlier only 7s and 20s components had been observed. Its molecular weight, 50,000, was the lowest observed for a serum protein; it was very asym- metrical; its partial specific volume was quite low-0. 70; the nitrogen content was low, 13g N/100g protein; the isoelectric point was low, pH 3. 5. The cause of the low nitrogen value was the high carbohydrate content of fetuin, 23%. The name fetuin (Latin; fetus) was proposed because this protein was the predominating component in the fetal serum, rapidly decreased, and finally disappeared in the newborn calf. " Proteins with fetuin-like properties were also identified in horse and sheep fetuses, and a small amount of a similar protein was identi- fied in human umbilical cord blood and fetal rabbit blood.
' In the early 1950s, with improved fractionation methods, many 2 new proteins were isolated and described. In 1954 Harold Deutsch prepared a new purified fraction of fetuin that was more uniform than Pedersen' s. During the same period, another fetoprotein, a-fetopro- 3 fetal blood. Like fetuin, this tein (AFP), was first described in human new component was also an a -globulin.
' In the early 1950s, with improved fractionation methods, many 2 new proteins were isolated and described. In 1954 Harold Deutsch prepared a new purified fraction of fetuin that was more uniform than Pedersen' s. During the same period, another fetoprotein, a-fetopro- 3 fetal blood. Like fetuin, this tein (AFP), was first described in human new component was also an a -globulin.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1995
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Research
Illustrations
10 farbige Abbildungen, 36 s/w Abbildungen
VIII, 180 p. 46 illus., 10 illus. in color.
Dimensions
Height: 254 mm
Width: 178 mm
Thickness: 11 mm
Weight
373 gr
ISBN-13
978-3-662-21900-3 (9783662219003)
DOI
10.1007/978-3-662-21898-3
Schweitzer Classification
Other editions
Content
1. Introduction.- 2. Structure of the Fetuins.- 3. Fetuin and the Cystatins.- 4. Functions of Fetuin.- 5. Fetuin in Plasma and Cerebrospinal Fluid.- 6. Fetuin in Tissue Development.- 7. Future and Conclusions.
