Histocompatibility Testing

Successful transplantation depends on the minimization of immunological differences between the donor and recipient tissues. These differences are based on polymorphisms of the human major histocompatibility complex and play a major role in determining the acceptance or rejection of allografts during transplantation. This study describes methods for the investigation of these polymorphisms at the gene and protein levels and their application to the clinical transplanation of human organs and bone marrow.