
The Evolution of Vertebrate Blood Clotting
Russell F. Doolittle(Author)
University Science Books,U.S. (Publisher)
Will be published approx. on 15. November 2012
Book
Hardback
232 pages
978-1-891389-81-8 (ISBN)
Description
This book charts the step-by-step evolution of vertebrate blood coagulation in the context of molecular evolution with a focus on the search for blood clotting genes in the genomes of non-mammalian vertebrates. An extensive glossary and guide to current literature combine to make this book an excellent resource for researchers and students alike.
More details
Edition
2012
Language
English
Place of publication
Mill Valley
United Kingdom
Target group
College/higher education
Product notice
Laminated cover
Dimensions
Height: 236 mm
Width: 182 mm
Thickness: 22 mm
Weight
675 gr
ISBN-13
978-1-891389-81-8 (9781891389818)
Schweitzer Classification
Person
RUSSELL DOOLITTLE is an Emeritus Professor at the University of California, San Diego, USA, where he has spent most of his long career. He received his PhD in Biochemistry from Harvard University in 1962. His research interests have centred on the structure and evolution of proteins in general and, more particularly, on blood clotting proteins, an interest he developed while a graduate student at Harvard. He is a member of the U.S. National Academy of Sciences, the American Academy of Arts and Sciences, and the American Philosophical Society.
Content
Preface.- Prologue.- PART I: LAYING THE GROUNDWORK .- Blood Clotting in Humans.- Clotting Inhibitors and Fibrinolysis.- Localizing Clots.- Proteins and Domains.- Fibrinogen and Fibrin.- Animals, Their Proteins and Phylogenetics.- Gene Duplications.- Genomes.- PART II: SEARCHING THROUGH GENOMES.- Genomes of Fish with Jaws.- Lamprey Clotting Genes.- Contact Factors and Other Embellishments.- Protochordate Genomes.- How the System Began.- Afterword.- Glossary.- Appendix.