
Present at the Flood
How Structural Molecular Biology Came About
Richard E. Dickerson(Author)
Oxford University Press Inc
Published on 1. May 2005
Book
Paperback/Softback
250 pages
978-0-87893-168-2 (ISBN)
Description
Present at the Flood tells the story of the rise of structural molecular biology-proteins and DNA-by immersing the reader in the original papers, written by the scientists who actually did the work. 187 pages from 42 essential scientific papers are reprinted, along with diagrams and commentaries to make them intelligible to the modern reader. The book achieves a personal note because the author was a worker in later years of the field and knew many of the key participants.
Reviews / Votes
The book is obviously a labor of love; it is copiously illustrated and peppered with humor. The volume was prepared as a text for a course. However, beyond such course work, it is also warmly recommended for all structural chemists whether or not versed in crystallography, because it contains a wealth of information and instruction about the structure elucidation of biological macromolecules, about the history of the field, and * what is especially rare in scientific literature * The book is particularly well-suited for classroom instruction. In fact, the text grew out of a graduate course in structural biology that Dickerson teaches at UCLA. His text provides most of the relevant literature in one convenient location and facilitates classroom discussion by including a set of focused conversation questions at the end of each chapter. It also provides a valuable introduction for non-structural biologists interested in the development of X-raycrystallography. * Scott A. Strobel, Structure * The book will clearly serve its intended purpose as an outline for a graduate course on the origins and methods of structural molecular biology, but it is also highly recommended for its insights into the lives and thought processes of those who laid the foundations of the field. * Fred Eiserling, Journal of Structural Biology * Dickerson has not only done a scholarly job of plotting a route through the scientific literature to reveal the key advances in structural molecular biology, he also introduces the experimental techniques (with many helpful diagrams) to explain X-ray diffraction and protein crystallography. The book provides the basis for a stimulating postgraduate course, or could be read by anyone who wants a better understanding of the 'giants' of 20th-century biology. * Linda A. Amos, The Quarterly Review of Biology * A must for students of structural biology. * Richard A. Wing, Yale Journal of Biology and Medicine *
More details
Edition
2005
Language
English
Place of publication
Sunderland
United Kingdom
Target group
College/higher education
Professional and scholarly
Dimensions
Height: 27.8 cm
Width: 22.8 cm
Thickness: 17 mm
Weight
1012 gr
ISBN-13
978-0-87893-168-2 (9780878931682)
Schweitzer Classification
Person
RICHARD E. DICKERSON Molecular Biology Institute, University of California, Los Angeles, USA.
Content
Introduction.- Your Cells are Not Micelles!.- Workers of the World, Cast off your Chains!.- The Folding and Coiling of Polypeptide Chains.- The Race for the DNA Double Helix.- How to Solve a Protein Structure.- High-Resolution Protein Structure Analysis.- The Knowledge Explosion.- Epilogue.- Appendix 3 : Irving Geis, the Molecular Vesalius.- Appendix 2: Highly Recommended Reading.- PART I: THE HISTORY OF WHAT WE TODAY CALL MOLECULAR BIOLOGY.- PART II: PERSONALITIES INVOLVED IN THE WORK.