DNA Interactions with Polymers and Surfactants
Iowa State University Press
Published on 1. April 2008
Book
Hardback
380 pages
978-0-8138-0646-4 (ISBN)
Description
"DNA Interactions with Polymers and Surfactants" provides a broad overview of the interaction of DNA with cosolutes in both bulk solution and at interfaces. It provides the basis for understanding the factors leading to complexation between DNA and different cosolutes as well as DNA adsorption at different interfaces, and covers DNA-cosolute interactions including simple metal ions, polyelectrolytes, spermine, spermidine, surfactants and lipids, and proteins. Theoretical information such as important correlations forces, are addressed, as well has more practical aspects, such as the biological significance of the interactions such as with chromatin and transfection.
More details
Language
English
Place of publication
Arnes, AI
United States
Target group
Professional and scholarly
ISBN-13
978-0-8138-0646-4 (9780813806464)
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Schweitzer Classification
Persons
Rita Dias is a guest post-doctorate at Lund University, Lund, Sweden Bjorn Lindman, Professor, Physical Chemistry, Chemical Center, Lund University, Lund, Sweden
Content
Introduction.Polylectrolytes: Physic-chemical Aspects and Biological Significance.Solution Behavior of Nucleic Acids.Individual DNA Molecules: Compaction and Decompaction.Interaction of DNA with Surfactants.DNA-DNA Interactions.Interaction of DNA with Cationic Polymers.Ineractions of DNA with Histones and Other Proteins.Hydration of DNA.Adsorption of DNA at solid and liquid interfaces.Interfacial DNA-Surfactant/Lipid Complexes.Electrostatic Theory of DNA-DNA and DNA-Cosolute interactions: Role of Correlation Forces.Simulations of Polyelectrolytes and polyelectrolyte-macroion systems.Relevance for Transfection of DNA-Cosolute interactions