Blood-Brain Barriers
From Ontogeny to Artificial Interfaces
1st Edition
Published on 3. March 2006
Book
Hardback
XXXII, 742 pages
978-3-527-31088-3 (ISBN)
Description
This first handbook to integrate developmental and cellular aspects combines the different structural and functional features involved in the regulation of brain perfusion and neuronal function. It highlights pharmacological and biomedical applications with sections on drug delivery and disease-related states as well as explaining in detail the role of astrocytes, shown to be an essential link between neurons and cerebral blood vessels. In addition the book studies how the structural elements interact in response to the dynamics of neuronal activities, necessitating adaptive mechanism of the interface. A significant part of the book describes new approaches to how the barrier can be surmised for drug delivery and how it can be mimicked by artificial in vitro systems for drug testing. Finally, the involvement of the barrier in brain diseases is considered, focusing on inflammatory and neurodegenerative disorders of the brain.
Covering basic knowledge as well as specific information dealing with very recent progress in blood-brain interface research, this book will be of interest to a broad audience.
Reviews / Votes
"The book is an excellent review of the present understanding of the blood-barrier, providing basic knowledge as well as current research results ... .[It] is very well structured and written." (Journal of Chemical Neuroanatomy, March 2008) "...the authors have succeeded in making a great leap forward towards a better understanding of the structure and function of cerebral microvessels. Hopefully the book will find a broad readership and become a benchmark for blood-brain barrier textbooks." (ChemMedChem)More details
Edition
1., Auflage
Language
English
Place of publication
Weinheim
Germany
Target group
Professional and scholarly
Neurobiologen, Zellbiologen, Biochemiker, Neurochemiker
Illustrations
151
99 s/w Abbildungen, 33 farbige Abbildungen, 19 s/w Tabellen
Illustrations (some col.)
Dimensions
Height: 24 cm
Width: 17 cm
Thickness: 49 mm
Weight
1792 gr
ISBN-13
978-3-527-31088-3 (9783527310883)
Schweitzer Classification
Persons
Rolf Dermietzel is Professor and head of the Department of Neuroanatomy and Molecular Brain Research at the Ruhr University in Bochum, Germany. He gained his PhD from the University Hospital in Essen, Germany, in 1970, before training in cell biology at the California Institute of Technology and the Marine Biological Institute in Woods Hole, MA. His research focuses on identifying the molecular make-up of the blood-brain barrier and the role of gap junctions in brain tissues. Professor Dermietzel has won several awards in electron microscopy, and co-authored three books in different fields of neurosciences, among them the bestselling Handbook of Neurotransmitters and Neuromodulators.
David C. Spray is Professor of Neuroscience and Medicine (Cardiology) at the Albert Einstein College of Medicine, NY. He obtained his PhD from the University of Florida College of Medicine in 1973, and is also Adjunct Professor of Biomedical Engineering at City College. His research has focused on physiological roles of gap junction channels, how alterations in gap junction expression and function lead to disease and whether novel types of gap junction-altering drugs may be therapeutically useful. Professor Spray is a foreign member of the Brazilian Academy of Sciences and has published some 350 full-length papers and book chapters.
Maiken Nedergaard received an M.D. from the University of Copenhagen, Denmark, in 1983, and her Ph.D. from the University of Copenhagen in 1988. She worked at Cornell University Medical College before joining the faculty of New York Medical College as Professor of Cell Biology in 1994. Since 2003 she has been on the faculty of the University of Rochester. Her work focuses on defining the role of astrocytes in synaptic plasticity, as well as in acute neurological diseases, including stroke, spinal cord injury and epilepsy. Recently Professor Nedergaard has been analyzing the significance of glutamatergic signaling in malignant gliomas.
Content
Introductory Preface: The blood-brain interfaces: An integrated concept (R. Dermietzel, D. Spray, M. Nedergaard)
ONTOGENY OF THE BLOOD-BRAIN-BARRIER
Development of the Blood-Brain Interface (B. Engelhardt)
Brain Angiogenesis and Barrier Genesis (K.-W. Kim)
Microvascular Influences on Progenitor Cell Mobilization and Fate in the Adult Brain (S. Goldman)
THE CELLS OF THE BLOOD-BRAIN INTERFACE: REVISITED
The endothelial frontier (H. Wolburg)
Pericytes and their contribution to the blood-brain-barrier (M. Ramsauer)
Brain Macrophages: Enigmas and Conundrums (G.I. Hatton)
The microglial component (I. Bechmann)
The bipolar astrocyte (J. Abbott)
Responsive astrocytic endfeet: the role of AQP4 in BBB development and functioning (A. Frigeri
HORMONAL AND ENZYMATIC CONTROL OF BRAIN VESSELS
The Role of Fibroblast Growth Factor 2 in Establishment and Maintenance
of the Blood-brain Barrier (B. Reuss)
Cytokine interaction with the blood-brain-barrier (W. Pan)
Insulin and the blood-brain barrier (W.A. Banks)
Glucocorticoid Hormones and Estrogens: Their Interaction with the Endothelial Cells of the Blood-Brain Barrier (J.-B. Dietrich)
Metalloproteases and the brain microvasculature (D. Krause)
CULTURING THE BLOOD BRAIN BARRIER
Culturing the blood-brain-barrier (R. Cecchelli)
Induction of blood-brain barrier properties in cultured endothelial cells (H.-J. Galla)
Artificial blood brain barriers (D. Janigro)
In silico prediction models for blood-brain barrier permeation (G. Ecker)
DRUG DELIVERY TO THE BRAIN
The Blood-Brain Barrier: Roles of the Multidrug Resistance Transporter P-Glycoproteon (R. Beliveau)
Targeting of neuropharmaceuticals by chemical delivery (N. Bodor)
Drug Delivery to the Brain by Internalizing Receptors at the Blood-Brain Barrier (A.G. de Boer)
VASCULAR PERFUSION
Blood-Brain Transfer and Metabolism of Oxygen (A. Gjedde)
Functional Brain Imaging (G. Dienel)
DISEASE-RELATED RESPONSE
Inflammatory response of the blood-brain interface (P. Faustmann)
Stroke and the Blood-Brain Interface (M.J. Cipolla)
Diabetes and the consequences for the blood-brain barrier (A.D. Mooradian)
Human parasitic disease in the context of the blood-brain-barrier - Effects, interactions, and transgression (D.A. Milner)
The healthy and diseased retina-blood interfaces (T. Chan-Ling)