Microbial Pathogenomics
1st Edition
Published on 27. August 2009
Book
Hardback
214 pages
978-3-8055-9192-8 (ISBN)
Description
'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'. 'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.
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Content
Editorial: Volff, J.-N.; Preface: de Reuse, H.; Bereswill, S.; Genome Comparison of Bacterial Pathogens: Wassenaar, T.M.; Bohlin, J.; Binnewies, T.T.; Ussery, D.W.; In silico Reconstruction of the Metabolic and Pathogenic Potential of Bacterial Genomes Using Subsystems: McNeil, L.K.; Aziz, R.K.; The Bacterial Pan-Genome and Reverse Vaccinology: Tettelin, H.; 'Guilty by Association' - Protein-Protein Interactions (PPIs) in Bacterial Pathogens: Schauer, K.; Stingl, K.; Helicobacter pylori Sequences Reflect Past Human Migrations: Moodley, Y.; Linz, B.; Helicobacter pylori Genome Plasticity: Baltrus, D.A.; Blaser, M.J.; Guillemin, K.; Genomics of Thermophilic Campylobacter Species: Gaskin, D.J.H.; Reuter, M.; Shearer, N.; Mulholland, F.; Pearson, B.M.; van Vliet, A.H.M.; Adaptation of Pathogenic E. coli to Various Niches: Genome Flexibility is the Key: Brzuszkiewicz, E.; Gottschalk, G.; Ron, E.; Hacker, J.; Dobrindt, U.; Role of Horizontal Gene Transfer in the Evolution of Pseudomonas aeruginosa Virulence: Qiu, X.; Kulasekara, B.R.; Lory, S.; The Genus Burkholderia: Analysis of 56 Genomic Sequences: Ussery, D.W.; Kiil, K.; Lagesen, K.; Sicheritz-Ponten, T.; Bohlin, J.; Wassenaar, T.M.; Genomics of Host-Restricted Pathogens of the Genus Bartonella: Engel, P.; Dehio, C.; Legionella pneumophila - Host Interactions: Insights Gained from Comparative Genomics and Cell Biology: Lomma, M.; Gomez Valero, L.; Rusniok, C.; Buchrieser, C.; A Proteomics View of Virulence Factors of Staphylococcus aureus: Engelmann, S.; Hecker, M.; Pathogenomics of Mycobacteria: Gutierrez, M.C.; Supply, P.; Brosch, R.; Author Index; Subject Index.