Metals in Cells
Published on 27. September 2013
Book
Hardback
600 pages
978-1-119-95323-4 (ISBN)
Description
Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs.
This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the "metallome"] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know.
The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
More details
Series
Edition
1. Auflage
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Product notice
sewn/stitched
Cloth over boards
Dimensions
Height: 287 mm
Width: 220 mm
Thickness: 32 mm
Weight
1880 gr
ISBN-13
978-1-119-95323-4 (9781119953234)
Schweitzer Classification
Other editions
Additional editions
Person
Prof. Robert A. Scott (Editor-in-Chief Encyclopedia of Inorganic and Bioinorganic Chemistry)
Distinguished Research Professor, University of Georgia, USA.
Prof. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences
Research in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, C. elegans and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.
Distinguished Research Professor, University of Georgia, USA.
Prof. Valeria Culotta, Biochemistry and Molecular Biology Department, Joint Departmental Affiliations Environmental Health Sciences
Research in the Culotta lab focuses on the role of metal ions and oxygen radicals in biology and disease. Metal ions such as copper, iron and manganese are not only trace nutrients but can be quite toxic. One mechanism of toxicity is through generation of reactive oxygen species (ROS) that have been implicated in numerous human disorders from neurodegeneration to cancer to aging. Through molecular genetic approaches and high through-put genetic screens in yeast, we have identified a number genes and pathways that are involved in transition metal and reactive oxygen metabolism. Virtually all are well conserved throughout eukaryotes including humans. Our laboratory uses a combination of yeast, C. elegans and cell culture systems at the crossroads of bioinorganic chemistry, cell biology and molecular genetics.
Content
Contributors xi
Series Preface xix
Volume Preface xxi
PART 1: INTRODUCTION 1
Mechanisms Controlling the Cellular Metal Economy 3
Benjamin A. Gilston and Thomas V. O'Halloran
PART 2: PROBING METALS AND CROSS TALK IN THE METALLOME 15
The Metallome 17
Vadim N. Gladyshev and Yan Zhang
Cyanobacterial Models that Address Cross-Talk in Metal Homeostasis 39
Carl J. Patterson, Rafael Pernil, Andrew W. Foster and Nigel J. Robinson
Sparing and Salvaging Metals in Chloroplasts 51
Crysten E. Blaby-Haas and Sabeeha S. Merchant
Fluorescent Probes for Monovalent Copper 65
M. Thomas Morgan, Pritha Bagchi and Christoph J. Fahrni
Fluorescent Zinc Sensors 85
Amy E. Palmer, Jose G. Miranda and Kyle P. Carter
X-Ray Fluorescence Microscopy 99
James E. Penner-Hahn
PART 3: MOVING METALS IN CELLS 111
Iron and Heme Transport and Trafficking 113
Yvette Y. Yien and Barry H. Paw
Iron in Plants 131
Jessica B. Weng and Mary Lou Guerinot
Transport of Nickel and Cobalt in Prokaryotes 145
Thomas Eitinger
Transport Mechanism and Cellular Functions of Bacterial Cu(I)-ATPases 155
Jose M. Arguello, Teresita Padilla-Benavides and Jessica M. Collins
Copper Transport in Fungi 163
Simon Labbe, Jude Beaudoin and Raphael Ioannoni
Structural Biology of Copper Transport 175
Adrian G. Flores, Christopher R. Pope and Vinzenz M. Unger
Zinc Transporters and Trafficking in Yeast 183
Yi-Hsuan Wu and David J. Eide
Cadmium Transport in Eukaryotes 195
Nathan Smith, Wenzhong Wei and Jaekwon Lee
PART 4: METALS IN REGULATION 207
Metal Specificity of Metallosensors 209
Khadine A. Higgins and David P. Giedroc
Metal Homeostasis and Oxidative Stress in Bacillus subtilis 225
Zhen Ma and John D. Helmann
Regulation of Manganese and Iron Homeostasis in the Rhizobia and Related alpha-Proteobacteria 237
Mark R. O'Brian
The Iron Starvation Response in Saccharomyces cerevisiae 249
Caroline C. Philpott and Pamela M. Smith
Hepcidin Regulation of Iron Homeostasis 265
Clara Camaschella and Laura Silvestri
NikR: Mechanism and Function in Nickel Homeostasis 277
Michael D. Jones, Andrew M. Sydor and Deborah B. Zamble
Regulation of Copper Homeostasis in Plants 289
Marinus Pilon and Wiebke Tapken
Regulation of Zinc Transport 301
Taiho Kambe
Selenoproteins--Regulation 311
Lucia A. Seale and Marla J. Berry
PART 5: METALS IN CELLULAR DAMAGE AND DISEASE 321
Metals in Bacterial Pathogenicity and Immunity 323
Jennifer S. Cavet
Manganese in Neurodegeneration 335
Daiana Silva Avila, Robson Luiz Puntel, Felix Antunes Soares, Joao Batista Teixeira da Rocha and Michael Aschner
Iron Sequestration in Immunity 349
Colin Correnti and Roland K. Strong
Molecular Basis of Hemochromatosis 361
Paul J. Schmidt
Copper in Brain and Neurodegeneration 373
Jeffrey R. Liddell, Ashley I. Bush and Anthony R. White
Copper Transporting ATPases in Mammalian Cells 395
Nan Yang and Svetlana Lutsenko
Copper in Immune Cells 409
Karrera Y. Djoko, Maud E.S. Achard and Alastair G. McEwan
Selenoenzymes and Selenium Trafficking: An Emerging Target for Therapeutics 421
William Self and Sarah Rosario
Resistance Pathways for Metalloids and Toxic Metals 429
Zijuan Liu, Christopher Rensing and Barry P. Rosen
PART 6: COFACTOR ASSEMBLY 443
Fe-S Cluster Biogenesis in Archaea and Bacteria 445
Harsimranjit K. Chahal, Jeff M. Boyd and F. Wayne Outten
Mitochondrial Iron Metabolism and the Synthesis of Iron-Sulfur Clusters 473
Andrew Dancis and Paul A. Lindahl
[FeFe]-Hydrogenase Cofactor Assembly 491
Eric M. Shepard, Amanda S. Byer, Eric S. Boyd, Kevin D. Swanson, John W. Peters and Joan B. Broderick
[NiFe]-Hydrogenase Cofactor Assembly 507
Basem Soboh and R. Gary Sawers
Copper in Mitochondria 517
Katherine E. Vest and Paul A. Cobine
Mo Cofactor Biosynthesis and Crosstalk with FeS 529
Florian Bittner and Ralf R. Mendel
Nitrogenase Cofactor Assembly 543
Jared A. Wiig, Chi Chung Lee, Markus W. Ribbe and Yilin Hu
Index 555