Problem Solving Through Precision Oncology
A Case Study Based Reference and Learning Resource
Published on 8. November 2016
Book
Paperback/Softback
272 pages
978-1-84692-111-7 (ISBN)
Description
Precision oncology offers a hugely exciting opportunity to personalise cancer treatments and prevention for the benefit of the individual but does present great challenges at present, both scientific and ethical. We now have the capacity to identify the abnormalities in genes and proteins that introduce the risk of individuals developing cancer and are responsible for the classical behaviour of a cancer. Having done this, healthcare teams are able to better diagnose cancer, evolve preventive strategies, and develop and deploy targeted cancer therapies. Precision oncology involves better prevention strategies and ensuring that therapeutic interventions can be concentrated on those who will benefit, reducing expense and sparing side effects for those who will not. This new educational resource provides an overview of the latest progress in developing precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. It includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community.
Reviews / Votes
Supported by the Association of Cancer PhysiciansMore details
Series
Language
English
Place of publication
Witney
United Kingdom
Publishing group
Evidence-Based Networks Ltd
Target group
College/higher education
Professional and scholarly
Illustrations
20 figures and images 10 algorithms 30 tables
Dimensions
Height: 238 mm
Width: 169 mm
Weight
580 gr
ISBN-13
978-1-84692-111-7 (9781846921117)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Persons
Ellen Copson, University Hospital, Southampton, UK;Peter Hall, University of Edinburgh, UK; Ruth Board, Lancashire Teaching Hospitals NHS Trust, UK; Gordon Cook, University of Leeds, UK; Peter Selby, St. James's University Hospital, Leeds, UK; Association of Cancer Physicians.
Content
1) Precision oncology - an introduction (including 100,000 genome project): Ellen Copson, Peter Hall, Ruth Board, Gordon Cook, Peter Selby 2) Testicular cancer a successful model for biomarker guided cancer care: Johnathan Joffe 3) Cancer susceptibility genes: Diana Eccles 4) Tumour biology and somatic genetics as they underpin precision oncology: Nicolai J Birkbak 5) Pharmacogenomics: Jean E Abraham 6) Introducing next generation sequencing into routine practice - the benefits and the challenges: Angela Hamblin 7) An introduction to proteomics and the discovery of new renal cancer biomarkers: Peter Selby 8) Myeloma: Gordon Cook 9) Lymphoma: Andy Davis 10) Stratified medicine in the UK: Colin Lindsay 11) The economic challenge of healthcare provision in precision oncology: Peter Hall 12) Clinical trials in precision oncology: Peter Selby 14) Developing diagnostic tests for precision oncology: Mike Messenger15) The use of circulating tumour-derived nucleic acids in precision oncology: Nick Turner, Charlotte Fribbens15) Ethical issues in precision oncology/cancer genetics: Angela FenwickCases / Corresponding Authors 1) A breast cancer patient with a BRCA1 mutation: Ellen Copson 2) A colorectal cancer patient with Lynch syndrome: Adam Januszewski 3) A patient with advanced melanoma for systemic therapy with a BRAF inhibitor: Samantha Turnbull4) Metastatic non-small cell lung cancer with activating EGFR mutation: Leena Mukherjee 5) A patient with an advanced gastrointestinal stromal tumour tested for a c-KIT mutation: Stefan Symeonides6) A case of relapsed myeloma with high risk cytogenics: Matthew Jenner 7) A case of young man with high-grade orbital lymphoma: Cathy Burton 8) Li Fraumeni: Hayley Mackenzie 9) VHL: Peter Selby 10) A breast cancer patient tested with Oncotype DX: Yun Yi Tan 11) A patient with ovarian cancer for whom treatment is guided by multi platform tumour molecular profiling: Elaine Dunwoodie 12) A teenager with a small round cell tumour and a diagnostic translocation: Nicola Hughes 13) Treatment based clinical prognostic factors and molecular profiling in medulloblastoma: Susan Short 14) A man with locally advanced Human Papilloma Virus (HPV) positive propharyngeal squamous cell carcinoma: Joseph J Sacco 15) A colorectal cancer patient: Colin Barrie16) A case of a man with advanced upper gastrointestinal cancer and poor physical fitness: Tim Underwood 17) A prostate cancer patient: Sebastian Trainor 18) An adult sarcoma patient: Salma Naheed, Peter Simmonds 19) A case of a woman with BRCA-mutated ovarian cancer: Barbara Stanley20) A case of high count T-ALL in a 2 yr old boy with treatment stratification based on MRD response: Amy Mitchell 21) Application of cancer genomics to routine care: Janessa Laskin