The Molecular Basis of Human Cancer

Part I. Introduction Cancer Epidemiology: Incidence and Etiology of Human Neoplasms William B. Coleman and Gregory J. Tsongalis Part II. Essential Concepts in Molecular Biology Essential Concepts and Techniques in Molecular Biology Sharon Collins Presnell Part III. Molecular Themes in Oncogenesis Cancer Genes John J. Reinartz Positive Mediators of Cell Proliferation in Neoplastic Transformation James N. Welch and Susan A. Chrysogelos Inactivation of Negative Growth Regulators During Neoplastic Transformation Kara N. Smolinski and Stephen J. Meltzer Part IV. Mechanisms of Mutation The Role of Genomic Instability in the Development of Human Cancer William B. Coleman and Gregory J. Tsongalis Chromosomes and Chromosomal Instability in Human Cancer Takashi Shimamoto and Kazuma Ohyashiki Hereditary Cancer Bruce M. Boman, Lael Melchert, and Jeremy Z. Fields Part V. Etiology of Human Cancers Evolution of Research in Cancer Etiology Lorenzo Tomatis and James Huff Cellular Responses to Chemical Carcinogens Edward L. Loechler, Bryan Henry, and Kwang-Young Seo Physical Agents in Human Carcinogenesis Cynthia R. Timblin, Yvonne Janssen-Heininger, and Brooke T. Mossman Viral Mechanisms of Human Carcinogenesis Felix Hoppe-Seyler and Karin Butz Part VI. Human Tumor Systems The Molecular Biology of Colorectal Carcinoma: Importance of the Wg/Wnt Signal Transduction Pathway J. Milburn Jessup, Gary Gallick, and Bo Liu Molecular Genetic Alterations in Primary Hepatocellular Neoplasms: Hepatocellular Adenoma, Hepatocellular Carcinoma, and Hepatoblastoma Joe W. Grisham The Molecular Basis of Breast Carcinogenesis April Charpentier and C. Marcelo Aldaz The Molecular Basis of Prostate Carcinogenesis Allen C. Gao and John T. Isaacs The Molecular Basis of Lung Carcinogenesis Kwun M. Fong, Yoshitaka Sekido, and John D. Minna The Molecular Basis of Skin Carcinogenesis Caterina Missero, Mariarosaria D'Errico, Gian Paolo Dotto, and Eugenia Dogliotti The Molecular Biology of Leukemias Arnold B. Gelb and L. Jeffrey Medeiros Molecular Genetic Applications to the Diagnosis of Non-Hodgkin's Lymphoma Gregory J. Tsongalis and William N. Rezuke Part VII. Future Directions Cancer Genetic Counseling Katherine Schneider, Kristen Shannon, Anu Chittenden, Elaine Hiller, and Stephanie Kieffer Molecular Genetic Diagnosis of Inherited Cancer Predisposition Elizabeth M. Petty and Beverly M. Yashar Novel Molecular Targets for Cancer Drug Discovery John K. Buolamwini Gene Therapy in the Treatment of Human Cancer Jesús Gómez-Navarro, Guadalupe Bilbao, and David T. Curiel