Calmodulin
Published in June 1988
Book
Hardback
396 pages
978-0-444-80945-2 (ISBN)
Description
Since its discovery as an activator of cyclic nucleotide phosphodiesterase in 1970, it has gradually become clear that calmodulin is a remarkable multifunctional protein that is responsible for mediating many of the actions of the second messenger calcium ions in eucartyotic cells. This book highlights the recent impressive advances in understanding the structure of the protein and its gene, how it recognises target proteins, and the complexities of the enzyme systems which it activates.
Since its discovery as an activator of cyclic nucleotide phosphodiesterase in 1970, it has gradually become clear that calmodulin is a remarkable multifunctional protein that is responsible for mediating many of the actions of the second messenger calcium ions in eucartyotic cells. This book highlights the recent impressive advances in understanding the structure of the protein and its gene, how it recognises target proteins, and the complexities of the enzyme systems which it activates.
Since its discovery as an activator of cyclic nucleotide phosphodiesterase in 1970, it has gradually become clear that calmodulin is a remarkable multifunctional protein that is responsible for mediating many of the actions of the second messenger calcium ions in eucartyotic cells. This book highlights the recent impressive advances in understanding the structure of the protein and its gene, how it recognises target proteins, and the complexities of the enzyme systems which it activates.
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
College/higher education
Professional and scholarly
Dimensions
Height: 230 mm
Width: 150 mm
ISBN-13
978-0-444-80945-2 (9780444809452)
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Schweitzer Classification
Content
Dedication. Editor's foreword. List of contributors. Chapter 1. Structure and evolution of the calmodulin family of calcium regulatory proteins (D.C. Wylie and T.C. Vanaman). 4 sections. References. Chapter 2. Organization and evolution of genes for calmodulin and other calcium binding proteins (A.R. Means, J.A. Putkey and P. Epstein). 5 sections. Acknowledgements. References. Chapter 3. Interaction of calmodulin with Ca 2+ and target proteins (C.B. Klee). 5 sections. References. Chapter 4. NMR studies of calmodulin in solution structure and dynamics in relation to function (J.S. Evans, B.A. Levine, R.J.P. Williams and M.R. Wormald). 10 sections. Acknowledgements. References. Chapter 5. Three-dimensional structure of calmodulin (Y.S. Babu, C.E. Bugg and W.J. Cook). 4 sections. Acknowledgements. References. Chapter 6. Myosin light chain kinases and caldesmon: biochemical properties and roles in skeletal and smooth muscle contractions (J.T. Stull). 5 sections. Acknowledgements. References. Chapter 7. The regulation of phosphorylase kinase activity by calmodulin and troponin (P. Cohen). 9 sections. References. Chapter 8. The calmodulin-dependent multiprotein kinase (P. Cohen). 15 sections. Acknowledgements. References. Chapter 9. Substrate specificities of calmodulin-dependent protein kinases (B.E. Kemp). 7 sections. References. Chapter 10. The calmodulin-regulated protein phosphatase (C.B. Klee and P. Cohen). 9 sections. References. Chapter 11. Calmodulin stimulated adenylate cyclases (A.M. Minocherhomjee, R.L. Shattuck and D.R. Storm). 2 sections. Acknowledgement. References. Chapter 12. Calmodulin-stimulated cyclic nucleotide phosphodiesterase isozymes (R.K. Sharma, M. Mooibroek and J.H. Wang). 6 sections. Acknowledgements. References. Chapter 13. Calmodulin in the transport of calcium across biomembranes (E. Carafoli, J. Krebs and M. Chiesi). 5 sections. References. Chapter 14. The role of calmodulin in plants (D. Marme). 5 sections. References. Chapter 15. Calmodulin and cytoskeletal function (W.B. Gratzer and A.J. Baines). 9 sections. References. Chapter 16. Calmodulin-binding domains on target proteins (D.K. Blumenthal and E.G. Krebs). 4 sections. Acknowledgements. References. Chapter 17. Criteria required to demonstrate calmodulin-dependent effects in vivo (P. Cohen and C.B. Klee). Acknowledgements. References. Subject Index.