Introduction to Design and Analysis of Experiments

To the Instructor. Sample Exam Questions. To the Student. Acknowledgments. 1. Introduction to Experimental Design. 1. The Challenge of planning a good experiment. 2. Three basic principles and four experimental designs. 3. The factor structure of the four experimental designs. 2. Informal Analysis and Checking Assumptions. 1. What analysis of variance does. 2. The six fisher assumptions. 3. Informal analysis, part 1: parallel dot graphs and choosing a scale. 4. Informal analysis, part 2: interaction graph for the log concentrations. 3. Formal Anova: Decomposing the Data and Measuring Variability, Testing Hypothesis and Estimating True Differences. 1. Decomposing the data. 2. Computing mean squares to measure average variability. 3. Standard deviation = root mean square for residuals. 4. Formal hypothesis testing: are the effects detectable? 5. Confidence intervals: the likely size of true differences. 4. Decisions About the Content of an Experiment. 1. The response. 2. Conditions. 3. Material. 5. Randomization and the Basic Factorial Design. 1. The basic factorial design ("What you do"). 2. Informal analysis. 3. Factor structure ("What you get"). 4. Decomposition and analysis of variance for one-way BF designs. 5. Using a computer [Optional]. 6. Algebraic notation for factor structure [Optional]. 6. Interaction and the Principle of Factorial Crossing. 1. Factorial crossing and the two-way basic factorial design, or BF[2]. 2. Interaction and the interaction graph. 3. Decomposition and ANOVA for the two-way design. 4. Using a computer [Optional]. 5. Algebraic notation for the two-way BF design [Optional]. 7. The Principle of Blocking. 1. Blocking and the complete block design (CB). 2. Two nuisance factors: the Latin square design(LS). 3. The split plot/repeated measures design (SP/RM). 4. Decomposition and analysis of variance. 5. Scatterplots for data sets with blocks. 6. Using a computer. [Optional]. 7. Algebraic notation for the CB, LS And SP/RM Designs. 8. Working with the Four Basic Designs. 1. Comparing and recognizing design structures. 2. Choosing a design structure: deciding about blocking. 3. Informal analysis: examples. 4. Recognizing alternative to ANOVA. 9. Extending the Basic Designs by Factorial Crossing. 1. Extending the BF design: general principles. 2. Three or more crossed factors of interest. 3. Compound within-blocks factors. 4.Graphical methods for 3-factor interactions. 5. Analysis of variance. 10. Decomposing a Data Set. 1. The basic decomposition step and the BF[1] design. 2. Decomposing data from balanced designs. 11. Comparisons, Contrasts, and Confidence Intervals. 1. Comparisons: confidence intervals and tests. 2. Adjustments for multiple comparisons. 3. Between-blocks factors and compound within-blocks factors. 4. Linear estimators and orthogonal contrasts [Optional]. 12. The Fisher Assumptions and How to Check Them. 1. Same SDs (s). 2. Independent chance errors (I). 3. The normality assumption (N). 4. Effects are additive (A) and constant (C). 5. Estimating replacement values for outliers. 13. Other Experimental Designs and Models. 1. New factor structures built by crossing and nesting. 2. New uses for old factor structures: fixed versus random effects. 3. Models with mixed interaction effects. 4. Expected mean square and f-ratios. 14. Continuous Carriers: A Visual Approach to Regression, Correlation and Analysis of Covariance. 1. Regression. 2. Balloon summaries and correlation. 3. Analysis of covariance. 15. Sampling Distributions and the Role of the Assumptions. 1. The logic of hypothesis testing. 2. Ways to think about sampling distributions. 3. Four fundamental families of distributions. 4. Sampling distributions for linear estimators. 5. Approximate sampling distributions for f-ratios. 6. Why (and when) are the models reasonable? Tables. Data Sources. Subject Index. Examples.