Multiple Drug Resistance in Cancer
Cellular, Molecular and Clinical Approaches
Published on 14. October 2012
Book
Paperback/Softback
VIII, 393 pages
978-94-010-4355-7 (ISBN)
Description
This book is an up-to-date review of current knowledge in the field of multiple drug resistance in human cancer. The literature up to the middle of 1993 is surveyed in specialist chapters written by different experts. Topics covered include the molecular genetics, cytogenetics and biochemistry of the
mdr
genes and P-glycoprotein; alternative transport proteins in MDR; topoisomerases I and II; cytochrome p450-enzymes and glutathione-
S
-transferases in MDR; cellular models for MDR in solid tumours and haemopoietic tumours; immunochemical and molecular biological techniques for detection of MDR-related gene expression; and clinical and pharmacological strategies to circumvent resistance. The book brings together a new combination of approaches to this serious clinical problem.
More details
Edition
Softcover reprint of the original 1st ed. 1994
Language
English
Place of publication
Dordrecht
Netherlands
Target group
Professional and scholarly
Research
Illustrations
VIII, 393 p.
Dimensions
Height: 260 mm
Width: 195 mm
Thickness: 22 mm
Weight
849 gr
ISBN-13
978-94-010-4355-7 (9789401043557)
DOI
10.1007/978-94-011-0826-3
Schweitzer Classification
Other editions
Additional editions
E-Book
12/2012
Springer
€53.49
Available for download
Book
02/1994
1st Edition
Kluwer Academic Publishers
€85.55
Article exhausted; check different version
Content
P-glycoprotein structure and evolutionary homologies.- Molecular analysis of the multidrug transporter.- Molecular cytogenetics of multiple drug resistance.- Antibodies in the study of multiple drug resistance.- Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug.- Topoisomerase I in multiple drug resistance.- Topoisomerase II in multiple drug resistance.- Glutathione-related enzymes, glutathione and multidrug resistance.- Pharmacologic circumvention of multidrug resistance.- Multidrug resistance (MDR) genes in haematological malignancies.- Human cell lines as models for multidrug resistance in solid tumours.- Studies on low-level MDR cells.- Differing patterns of cross-resistance resulting from exposures to specific antitumour drugs or to radiation in vitro.- The use of reverse transcriptase-polymerase chain reaction (RT-PCR) to investigate specific gene expression in multidrug-resistant cells.- Mathematical models for multidrug resistance and its reversal.- The biology of radioresistance: similarities, differences and interactions with drug resistance.- Kinetic resistance to anticancer agents.- Cytochromes P450 and drug resistance.- Role of matrix metalloproteinases in invasion and metastasis: biology, diagnosis and inhibitors.- Clinical significance of cellular resistance in tumours to cytotoxic chemotherapy and radiotherapy.- Key word index.