Asymmetric Synthesis II

CATALYTIC ENANTIOSELECTIVE ALKYLATION OF PROCHIRAL KETONE ENOLATES
Background
Strategy and Results
Asymmetric Allylic Alkylation in Total Synthesis
Conclusions

POINT-TO-PLANAR CHIRALITY TRANSFER IN TOTAL SYNTHESIS: SCALABLE AND PROGRAMMABLE SYNTHESIS OF HAOUAMINE A AND ITS ATROPISOMER
Introduction
Synthetic Strategy Featuring Point-to-Planar Chirality Transfer
Programmable Synthesis of Haouamine A and Its Atropisomer

TETHERED AMINOHYDROXYLATION
Introduction and Background
Tethered Aminohydroxylation
Amide-Based Reoxidants
Evidence for the Mechanism of the TA Reaction
Applications in Organic Synthesis
Conclusion and Future Work

ORGANOCATALYZED TRANSFORMATIONS OF A, B-UNSATURATED CARBONYL COMPOUNDS THROUGH IMINIUM ION INTERMEDIATES

THE RENAISSANCE OF SILICON-STEREOGENIC SILANES: A PERSONAL ACCOUNT
Background
Results
Conclusion

ASYMMETRIC DIENAMINE ACTIVATION
Introduction
Historic Background
Results
Conclusion

ASYMMETRIC BRØNSTED ACID CATALYSIS
Introduction and Background
Strategy
Results
Summary

QUATERNARY STEREOGENIC CENTERS BY ENANTIOSELECTIVE B-CARBON ELIMINATIONS FROM TERT-CYCLOBUTANOLS
Background
Objective: Enantioselective Formation of Quaternary Stereogenic Centers in Combination with Reactive Alkyl-Rhodium
Intermediates
Selective Generation of the Alkyl-Rhodium Species and Its Downstream Reactivities

TOTAL SYNTHESIS OF OSELTAMIVIR AND ABT-341 USING ONE-POT TECHNOLOGY
Introduction
Results
Conclusions

ENANTIOSELECTIVE ANNULATIONS WITH CHIRAL N-MESITYL N-HETEROCYCLIC CARBENES
Introduction
Catalytic Generation of Chiral Enolate Equivalents
Catalytic Generation of Homoenolate Equivalents
Enantioselective Cascade Reactions Catalyzed by Chiral N-Heterocyclic Carbenes
Catalytic Annulations via a, ß-Unsaturated Acyl Azoliums
Conclusions

ASYMMETRIC COUNTERANION-DIRECTED CATALYSIS (ACDC)
Concept
Application of ACDC to Organocatalysis
Application of ACDC to Transition Metal Catalysis
Application of ACDC to Lewis Acid Catalysis

ENANTIOSELECTIVE ORGANO-SOMO CATALYSIS: A NOVEL ACTIVATION MODE FOR ASYMMETRIC SYNTHESIS
Background
Objective
Results

ENANTIOSELECTIVE PASSERINI REACTION
Introduction
Background
Results
Conclusion and Perspective

RAPID ENANTIOMERIC EXCESS DETERMINATION

ASYMMETRIC CATALYSIS OF REVERSIBLE REACTIONS
Thermochemistry of Asymmetric Catalyses Close to the Equilibrium
Kinetic Modeling of a Reversible Asymmetric Catalytic Reaction
Case Study: a Reversible Asymmetric Organocatalytic Reaction
Conclusions

EXPLOITING FLUORINE CONFORMATIONAL EFFECTS IN ORGANOCATALYST DESIGN: THE FLUORINE?IMINIUM ION GAUCHE EFFECT

DUTCH RESOLUTION

CONSTRUCTION OF ANTI-ME-OH VICINAL RELATIONSHIPS IN POLYKETIDES
Introduction
Marshall - Tamaru Reaction
Conclusions

PHOTOSWITCHABLE GENERAL BASE CATALYSTS
Introduction and Background
Strategy and Results
Outlook

ASYMMETRIC HALONIUM ADDITION TO OLEFINS
Introduction
Intramolecular Lactonizations, Etherifications, and Aminations
Polyene Cyclizations
Intermolecular Additions to Alkenes
Conclusion

CATALYTIC ASYMMETRIC GOSTELI - CLAISEN REARRANGEMENT (CAGC)

BIOMIMETIC TOTAL SYNTHESIS OF THE PENIFULVIN FAMILY
Introduction
The Penifulvin Family: Isolation and Biogenetic Origin
Total Syntheses of Penifulvins A, B, and C
Summary

CATALYST-CONTROLLED 1,3-POLYOL SYNTHESES

ENANTIOSELECTIVE CARBONYL ALLYLATION AND CROTYLATION FROM THE ALCOHOL OXIDATION LEVEL VIA C?C BOND FORMING TRANSFER HYDROGENATION
Introduction and Background
Strategy
Results

STEREOSELECTIVE SYNTHESIS WITH HYPERVALENT IODINE REAGENTS

ASYMMETRIC GOLD-CATALYZED REACTIONS
Introduction
Diphosphine-Gold Complexes in Enantioselective Catalysis
Monophosphine-Gold Complexes in Enantioselective Catalysis

ASYMMETRIC CATALYSIS IN THE TOTAL SYNTHESIS OF LIPIDS AND POLYKETIDES
Background
Tuberculostearic Acid: One Isolated Methyl Group
Ant Pheromones: Vicinal Methyl Branches
Deoxypropionates: 1,3-Methyl Arrays
Membrane-Spanning Lipids: 1,4-Dimethyl Units
Saturated Isoprenoids: 1,5-Methyl Arrays

THE EVOLVING ROLE OF BIOCATALYSIS IN ASYMMETRIC SYNTHESIS
Background - First- and Second-Generation Biotransformations
Results - Third-Generation Biotransformations
Conclusions and Future Perspectives

BIFUNCTIONAL THIOUREA CATALYSTS
Background
Results


CATALYTIC ASYMMETRIC (4 + 3) CYCLOADDITIONS USING ALLENAMIDES
Introduction and Background
Strategy
Results
Conclusion

APPLICATION OF THE ACHMATOWICZ REARRANGEMENT FOR THE SYNTHESIS OF OLIGOSACCHARIDES
Introduction
De novo Approach to Carbohydrates
An Iterative Pd-Catalyzed Glycosylation and Bidirectional Postglycosylation
Application to the Synthesis of the Anthrax Tetrasaccharide

ASYMMETRIC C - C BOND FORMATION USING CHIRAL PHOSPHORIC ACID
Background
Results
Conclusions and Future Perspectives

ASYMMETRIC C - H BOND FUNCTIONALIZATION
Background
Results
Conclusions and Future Perspectives

ASYMMETRIC C - C BOND FORMATION USING CHIRAL GUANIDINE CATALYSTS
Background
Catalyst Design and Results

ENANTIOSELECTIVE SYNTHESIS OF LACTONES VIA RH-CATALYZED KETONE HYDROACYLATION
Background and Introduction
Strategy and Results
Conclusions and Future Directions

RADICAL HALOALKYLATION

ASYMMETRIC HYDROVINYLATION OF ALKENES
Introduction
New Protocols for the Heterodimerization of Ethylene/Propylene and Vinylarenes, 1,3-Dienes, and Norbornene
Catalytic Asymmetric Hydrovinylation Reactions: Effects of Hemilabile Ligands
All-Carbon Quaternary Centers via Catalytic Asymmetric HV
Hydrovinylation (HV) of 1,3-Dienes and Asymmetric Variations
Asymmetric Hydrovinylation of Unactivated Linear 1,3-Dienes Using Co(II) Catalysis
Scope and Applications of Hydrovinylation Reactions: Exocyclic Stereocontrol
A Stereoselective Route to either Steroid-C20(S) or -C20(R) Derivatives
Asymmetric Hydrovinylation of Strained Alkenes
Conclusions and Future Perspectives

HETEROCYCLE CONSTRUCTION VIA ASYMMETRIC RHODIUM-CATALYZED CYCLOADDITIONS
Background
Strategy
Results
Application to Other Reactions
Conclusion and Future Perspectives

N-HETEROCYCLIC CARBENE-CATALYZED ALDOL DESYMMETRIZATIONS
Introduction
Strategy and Results
Application to the Syntheses of Bakkenolides I, J, and S
Conclusion

STRATEGIES FOR THE ASYMMETRIC TOTAL SYNTHESIS OF NATURAL PRODUCTS: `'CHIRAL POOL' VERSUS CHIRAL CATALYSTS
Introduction
Catalytic Stereoselective Total Synthesis
Natural Product Synthesis Starting from Chiral, Nonracemic Starting Materials
Conclusion

DYNAMIC KINETIC ASYMMETRIC TRANSFORMATIONS INVOLVING CARBON - CARBON BOND CLEAVAGE
Background
Donor - Acceptor Cyclopropanes as DYKAT Substrates
Lewis Acid Catalysis
Palladium Catalysis
Deracemization of Tertiary Propargyl-Allyl Alcohols via Rhodium-Catalyzed Sequential Rearrangement/Enantioselective Conjugate Addition
Conclusion

IRON-CATALYZED ALLYLIC SUBSTITUTIONS
Allylic Substitutions Catalyzed by the Hieber-Anion [Fe(CO)3(NO)]-
Allylic Substitutions Catalyzed by Fe2(CO)9

ASYMMETRIC CONIA-ENE CARBOCYCLIZATIONS
Introduction and Background: the Conia-ene Reaction
Strategy: Organo/Metal Cooperative Catalysis
Results

TACTICS AND STRATEGIES IN THE TOTAL SYNTHESIS OF CHLOROSULFOLIPIDS
Background
Stereoselective Synthesis of vic-Dichloride Fragments
Total Synthesis of Hexachlorosulfolipid
Conclusions

LINEAR FREE ENERGY RELATIONSHIPS (LFERS) IN ASYMMETRIC CATALYSIS
Introduction and Background
Hammett Electronic Parameters and Their Application to (salen)Mn(III)-Catalyzed Asymmetric Epoxidation Reactions
Relating Brønsted Acidity to Enantiomeric Ratio in an Asymmetric Hydrogen-Bond-Catalyzed Diels-Alder Reaction
An LFER Describing the Influence of Steric Bulk in a Nozaki?Hiyama - Kishi Asymmetric Allylation of Acetophenone
Correlating Quadrupole Moment to Enantioselectivity in Cation-p-Mediated Asymmetric Polycyclization
Simultaneously Correlating Hammett and Charton Parameters to Enantioselectivity in Two-Dimensional Free Energy Relationships
Conclusions

ASYMMETRIC DIAMINATION OF ALKENES
Introduction and Background
Strategy
Results

ENZYMATIC ASYMMETRIC SYNTHESIS OF TERTIARY ALCOHOLS
Introduction
YerE - a Unique ThDP-Dependent Enzyme
Hydroxynitrile Lyases
Conclusion

OXIDATIVE DEAROMATIZATION AND ORGANOCATALYTIC DESYMMETRIZATION
Introduction
Desymmetrization of Cyclohexadienones
A One-Pot Oxidative Dearomatization and Catalytic Desymmetrization
Oxo- and Aza-Michael Additions
Further One-Pot Methods for Oxidative Dearomatization and Catalytic Desymmetrization
Alkylative Dearomatization
Summary

TOTAL SYNTHESIS OF ALL (-)-AGELASTATIN ALKALOIDS
Introduction
Biosynthetically Inspired Plan for Total Synthesis
Total Synthesis of the Agelastatin Alkaloids