Blood Substitutes: Principles, Methods, Products and Clinical Trials....
Vol. 2
Published in 1998
Book
Hardback
XVIII, 236 pages
978-3-8055-6633-9 (ISBN)
Description
This volume, the second in a two-volume series on blood substitutes, presents a continuation of the work of Dr. T.M.S. Chang, known to many as a true pioneer for his early research in blood substitutes. While the first volume was single-authored and explored the many problems associated with hemoglobin replacement, this book brings together the work of many experts in the field who offer solutions to these problems, giving an overview of all the blood substitutes currently in phase II or phase III clinical trials in patients. Chapters cover topics such as surgical indications of blood substitutes, perfluorochemicals, and hemoglobin lipid vesicles as blood substitutes.
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Content
Part I Present status of blood substitutes in phase II and phase III clinical trials: donor blood uses in surgery and the potential for "blood substitues"; the clinical development of human polymerized haemoglobin; blood and HemAssist (DCLHb) - potentially a complementary therapeutic team; Hemolink, an o-Raffinose crosslinked haemoglobin-based oxygen carrier; overview of preclinical and clinical efficacy of biopure's HBOC's; fluorocarbon-based oxygen-delivery - basic principles and product development; perfluorochemical emulations - future alternatives to transfusion. Part II Future generations of blood substitutes: cell-free haeomoglobin and tissue oxidants - probing the mechanisms of haemoglobin cytotoxicity; crosslinked haeomglobin-superoxide dismutase-catalase - a second generation haeomoglobin based substitute with antioxidant activities; lipsome delivery of haemoglobin - molecular and cellular interactions in the vascular pool; nanoencapsulation of haemoglobin and red blood cell enzymes based on nanotechnology and biodegradable polymer.