Catecholamines I

1 Transport and Storage of Catecholamines in Vesicles.- A. Introduction.- B. Biogenesis.- C. Uptake.- D. Stroage.- E. References.- 2 Occurrence and Mechanism of Exocytosis in Adrenal Medulla and Sympathetic Nerve.- A. Introduction.- B. Evidence for Exocytosis.- C. Mechanism of Exocytosis.- D. References.- 3 Monamine Oxidase.- A. Introduction.- B. Classification.- C. Distribution and Localization.- D. Properties of the Enzyme.- E. Kinetics of the Reaction.- F. Reaction Mechanism.- G. Specificity.- H. The Influence of Membrane Environment.- J. Multiple Forms.- K. Multiple Forms as an In Vivo Reality and Their Function.- L. Inhibitors.- M. Physiological Role and Functional Activity of MAO; Biochemical and Behavioural Correlates.- N. Psychiatric and Neurological Disorders: MAO Activity and MAO Inhibitors as Drugs.- O. Future Perspectives.- P. Addendum.- Q. References.- 4 The Transport of Amines Across the Axonal Membranes of Noradrenergic and Dopaminergic Neurones.- A. Introduction.- B. Neuronal Uptake.- C. Neuronal Amine Metabolism.- D. Neuronal Efflux.- E. Proposed Mechanism of Neuronal Uptake: A Summing up.- F. References.- 5 The Mechanism of Action of Indirectly Acting Sympathomimetic Amines.- A. Introduction.- B. The Adrenergic Nerve Ending.- C. The Experimental Models.- D. Carrier-Mediated Uptake of (+)-Amphetamine.- E. The Release of 3H-Noradrenaline After Inhibition of MAO and of Vesicular Uptake.- F. Factors Involved in the Release of Axoplasmic 3H-Noradrenaline.- H. The Co-transport of Sodium.- G. The Release of 3H-Noradrenaline from Adrenergic Nerve Endings with Intact Storage Vesicles and Intact MAO (COMT Inhibited).- H. The Effects of Indirectly Acting Amines in the Presence of a Reserpine-like Compound.- J. Factors Which Influence the 3H-Noradrenaline-Releasing Effect of Indirectly Acting Amines.- K. The Release by Indirectly Acting Amines of Dopamine from Dopaminergic Nerve Endings.- L. Conclusions.- M. References.- 6 The Extraneuronal Uptake and Metabolism of Catecholamines.- A. Introduction.- B. Uptake2.- C. The Extraneuronal Metabolizing Systems.- D. Supersensitivity to Catecholamines After Inhibition of the Extraneuronal O-Methylating System.- E. The Interaction Between the Neuronal and the Extraneuronal Sites of Loss.- F. Conclusions: A Comparison of Uptake2 with Uptake1.- G. References.- 7 Catecholamines Receptors.- A. Introduction.- B. Relationship of Catecholamine Receptors to Effector Systems.- C. In Vitro Binding Assays.- D. In Vitro Properties of Adrenoceptors.- E. Localization of Catecholamine Receptors.- F. Multiplicity of Catecholamine Receptor Subtypes.- G. Regulation of the Sensitivity of Catecholamine Receptor Systems.- H. Agonist-Induced Desensitization.- J. Ontogeny of Catecholamine Receptors in the Central Nervous System.- K. Solubilization, Purification, and Reconstitution of Catecholamine Receptor/Effector Systems.- L. Molecular Cloning of Catecholamine Receptors.- M. Conclusion.- N. References.- 8 Presynaptic Receptors on Catecholamine Neurones.- A. Introduction and Definition of Terms.- B. The Dopamine Autoreceptor.- C. Presynaptic Heteroreceptors Modulating Dopamine Function..- D. Autoadrenoceptors.- E. Presynaptic Dopamine Receptors Modulating Noradrenaline Release.- F. Conclusions.- G. References.- 9 Adaptive Supersensitivity.- A. Introduction.- B. The Induction of Adaptive Supersensitivity.- C. Characteristics of Adaptive Supersensitivity.- D. Possible Mechanisms for Changes in Sensitivity of Effector Cells and Evidence Supporting or Opposing these Mechanisms.- E. Summary and Conclusions.- F. References.