
Steroids and Neuronal Activity
Symposium Proceedings
CIBA Foundation symposium(Author)
Wiley (Publisher)
Published on 24. October 1990
Book
Hardback
294 pages
978-0-471-92689-4 (ISBN)
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Description
Steroids and Neuronal Activity Chairman: M.A. Simmonds 1990 Classical studies on steroid hormones have been concerned with their regulation of protein synthesis via the modulation of genomic transcription. However, many of the actions of these hormones occur too rapidly to be explained in this way, particularly their effects on the central nervous system. Recent discoveries have shown that steroids can modulate the activity of certain neurotransmitters. GABA (gamma-aminobutyric acid) is an important regulator of neuronal activity in the CNS; its inhibitory action is mediated by the GABAA receptor and is potentiated by steroids. The mechanisms by which this is achieved are being investigated in electrophysiological and ligand binding studies described in this volume. The effects of steroids on dopamine and other receptors coupled to adenylate cyclase or to protein kinase C are also considered. The binding of steroids to cell membranes, the components involved and the outcome of such interactions are all discussed. These basic studies also have clinical implications.
The use of glucocorticoid steroids in the attenuation of neuronal damage after stroke or other trauma is being investigated, as is the role of ovarian steroids as anaesthetics and as anticonvulsants. The volume concludes with a review of glucocorticoid effects on long-term potentiation in the CNS. Related Ciba Foundation Symposia: No 123 Antidepressants and receptor function Chairman: D.L. Murphy 1986 ISBN 0 471 91089 9 No 152 The biology of nicotine dependence Chairman: L.L. Iversen 1990 ISBN 0 471 92688 4
The use of glucocorticoid steroids in the attenuation of neuronal damage after stroke or other trauma is being investigated, as is the role of ovarian steroids as anaesthetics and as anticonvulsants. The volume concludes with a review of glucocorticoid effects on long-term potentiation in the CNS. Related Ciba Foundation Symposia: No 123 Antidepressants and receptor function Chairman: D.L. Murphy 1986 ISBN 0 471 91089 9 No 152 The biology of nicotine dependence Chairman: L.L. Iversen 1990 ISBN 0 471 92688 4
More details
Series
Language
English
Place of publication
Chichester
United Kingdom
Publishing group
John Wiley and Sons Ltd
Target group
College/higher education
Professional and scholarly
Illustrations
57 line drawings, 1 half-tone, tables, index
Dimensions
Height: 255 mm
Width: 135 mm
Weight
580 gr
ISBN-13
978-0-471-92689-4 (9780471926894)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions

Derek J. Chadwick | Kate Widdows
Steroids and Neuronal Activity
E-Book
04/2008
1st Edition
Wiley
€121.99
Available for download
Content
Partial table of contents: Steroid Effects on Neuronal Activity: When Is the Genome Involved? (B. McEwen, et al.). Steroid Binding at sigma Receptors: CNS and Immunological Implications (T. Su, et al.). Effects of Progesterone and Its Metabolites on Neuronal Membranes (V. Ramirez, et al.). Effect of Oestradiol on Dopamine Receptors and Protein Kinase C Activity in the Rat Pituitary: Binding of Oestradiol to Pituitary Membranes (D. Joubert-Bression, et al.). Effects of Prostaglandin E2 and Progesterone on Rat Brain Synaptosomal Plasma Membranes (G. Deliconstantinos). Steroids and Neuronal Destruction or Stabilization (E. Hall). Early and Late Effects of Steroid Hormones on the Central Nervous System (B. Dubrovsky, et al.). Index of Contributors. Subject Index.