Cell Culture and Upstream Processing
1st Edition
Published on 29. March 2007
Book
Paperback/Softback
204 pages
978-0-415-39969-2 (ISBN)
Description
Upstream processing refers to the production of proteins by cells genetically engineered to contain the human gene which will express the protein of interest. The demand for large quantities of specific proteins is increasing the pressure to boost cell culture productivity, and optimizing bioreactor output has become a primary concern for most pharmaceutical companies. Each chapter in Cell Culture and Upstream Processing is taken from presentations at the highly acclaimed IBC conferences as well as meetings of the European Society for Animal Cell Technology (ESACT) and Protein Expression in Animal Cells (PEACe) and describes how to improve yield and optimize the cell culture production process for biopharmaceuticals, by focusing on safety, quality, economics and operability and productivity issues.
Cell Culture and Upstream Processing will appeal to a wide scientific audience, both professional practitioners of animal cell technology as well as students of biochemical engineering or biotechnology in graduate or high level undergraduate courses at university.
Cell Culture and Upstream Processing will appeal to a wide scientific audience, both professional practitioners of animal cell technology as well as students of biochemical engineering or biotechnology in graduate or high level undergraduate courses at university.
More details
Language
English
Place of publication
London
United Kingdom
Target group
College/higher education
Professional and scholarly
Postgraduate and Professional
Illustrations
118 s/w Abbildungen, 5 s/w Photographien bzw. Rasterbilder, 54 s/w Zeichnungen, 12 s/w Tabellen
12 Tables, black and white; 54 Line drawings, black and white; 5 Halftones, black and white; 118 Illustrations, black and white
Dimensions
Height: 246 mm
Width: 174 mm
Weight
380 gr
ISBN-13
978-0-415-39969-2 (9780415399692)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
Michael Butler
Cell Culture and Upstream Processing
E-Book
08/2007
Taylor & Francis
€158.99
Available for download
Michael Butler
Cell Culture and Upstream Processing
E-Book
08/2007
Taylor & Francis
€158.99
Available for download
Person
Michael Butler-Associate Dean of Science; Professor of Cell Technology, Department of Microbiology, School of Science, University of Manitoba, Winnipeg, Canada
Content
1. Cell Line Development and Culture Strategies: Future Prospects to Improve Yields 2. Use of DNA Insulator Elements and Scaffold / Matrix-Attached Regions for Enhanced Recombinant Protein Expression 3. Targeted Gene Insertion to Enhance Protein Production From Cell Lines 4. Recombinant Human IgG Production From Myeloma and Chinese Hamster Ovary Cells 5. Cell Culture Media Development: Customization of Animal Origin-Free Components and Supplements 6. Post-Translational Modification of Recombinant Proteins 7. Metabolic Engineering to Control Glycosylation 8. An Alternative Approach: Humanization of N-glycosylation Pathways in Yeast 9. Perfusion or Fed-Batch? A Matter of Perspective