
Oncogenes
An Introduction to the Concept of Cancer Genes
Springer (Publisher)
Published on 17. May 1988
Book
Paperback/Softback
XV, 300 pages
978-0-387-96423-2 (ISBN)
Description
"Cancer viruses" have played a paradoxical role in the history of cancer research. Discovered in 1911 by Peyton Rous (1) at the Rockefeller Institute, they were largely ignored for several decades. Witness his eventual recognition for a Nobel Prize, but not until 1966-setting an all time record for latency, and testimony to one more advantage of longevity. In the 1950s, another Rockefeller Nobelist, Wendell Stanley, spearheaded a campaign to focus attention on viruses as etiological agents in cancer, his plat form having been the chemical characterization of the tobacco mosaic virus as a pure protein-correction, ribonucleoprotein-in 1935 (2). This doctrine was a centerpiece of the U.S. National Cancer Crusade of 1971: if human cancers were caused by viruses, the central task was to isolate them and prepare vaccines for immunization. At that point, many observers felt that perhaps too much attention was being devoted to cancer viruses. It was problematic whether viruses played an etiological role in more than a handful of human cancers.
More details
Edition
1st ed. 1988. Corr. 2nd printing
Language
English
Place of publication
New York
United States
Target group
College/higher education
Research
Illustrations
33 s/w Abbildungen, 4 farbige Abbildungen
XV, 300 p. 37 illus., 4 illus. in color.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 18 mm
Weight
487 gr
ISBN-13
978-0-387-96423-2 (9780387964232)
DOI
10.1007/978-1-4612-3718-1
Schweitzer Classification
Other editions
Additional editions

Kathy B. Burck | Edison T. Liu | James W. Larrick
Oncogenes
An Introduction to the Concept of Cancer Genes
E-Book
12/2012
Springer
€96.29
Available for download
Persons
Content
1 Introduction.- 2 Assays: Tools of the New Biology.- 3 Viruses and Oncogenes.- 4 Human T Cell Lymphotropic/Leukemia Viruses.- 5 Cellular Proto-oncogenes.- 6 Oncogenes and Human Cancers.- 7 src and Related Protein Kinases.- 8 Growth Factors and Receptors.- 9 ras Family of Oncogenes.- 10 myc and Other Nuclear Oncogenes.- 11 Additional Oncogenes.- 12 Transgenic Mice: Direct In Vivo Assay for Oncogenes.- 13 Potential Diagnostic Uses of Oncogenes.- 14 Potential Therapeutic Applications of Oncogenes.- 15 Oncogene Paradigm: Contribution to a Fundamental Understanding of Malignancy.- Appendix: Oncogenes and Related Genes.