Variability in Response to Anti-Rheumatic Drugs
Published on 1. July 1993
Book
Hardback
227 pages
978-3-7643-2869-6 (ISBN)
Description
Therapy of rheumatiod arthritis is undergoing dramatic chamges. Greater appreciation of the long-term outcomes of this disease and the impacts of treatments has resulted in a more aggressive approach to therapy, especially in the early stages. An increasingly diverse array of anti-rheumatic drugs with novel effects on inflammation and the immune system confronts us. One factor remains constant; individual response to anti-rheumatic therapy is highly variable, thus providing an important approach to understanding the heterogeneity of the disease process, as well as the mechanisms of drug action. Experts of international repute address in this volume relevant aspects of recent research into non-steroidal anti inflanunatory drugs, stereochemistry, pharmacodynamics and pharmacokinetics, trials and trial design, combination therapy, new and old disease-modifying anti-rheumatic drugs, adverse reactions, side effects. The result is a state-of-the-art review of anti-rheumatic drug therapy. Variability in Response to Anti-Rheumatic Drugs is a valuable source of information for rheumatic disease researchers and pharmacologists, rheumatologists, as well as general physicians and internists.
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Content
PREFACE. NON-STEROIDAL ANTI-INFLAMMATORY DRUGS. Variability in Response to NSAIDS: What Progress? R.O. DAY Paracetamol in rheumatoid arthritis P. SEIDEMAN Stereochemical Contributions to Variability in Response to NSAIDs Chiral NSAIDS: So What? K.M. WILLIAMS Metabolic chiral inversion of 2-arylpropionates in different tumor cell lines S. MENZEL-SOGLOWEK, G. GEISSLINGER and K. BRUNE (R)-Flurbiprofen: isomeric ballast or active entity of the racemic compound G. GEISSLINGER, S. M-ENZEL-SOGLOWEK and K. BRUNE Further Factors Leading to Variability in Response to NSAIDs Mechanisms of NSAIDs on joint destruction in osteoarthritis K.D. RAINSFORD Pharmacokinetics and phan-nacodynamics of non-steroidal anti-inflammatory drugs in synovial fluid P. NETTER,B. BANNWARTH, F. LAPICQUE, F. DEMOTES-MAINARD, T. SCHCEVERBEKE and P. GILLET Biliary elimination of aspirin after oral and intravenous administration in patients BRUNE, B. NUERNBERG and H.T. SCHNEIDER Mechanisms of gastrointestinal damage by NSAIDs K.D. RAINSFORD TRIALS AND TRIAL DESIGN Variability in individual responses of 532 patients with rheumatoid arthritis to first line and second-line drugs T. PINCUS and L.F. CALLAHAN Towards more informative pilot studies with new anti-rheumatic drugs M.H. LIANG and R.B. BRIGHAM Limitations to standard randomized controlled clinical trials to evaluate combination therapies in rheumatic diseases T. PINCUS COMBINATION THERAPY Combination therapy in rheumatoid arthritis P. M. BROOKS Comparison of clinical effects of bucillamine between additive combination and single administration study in rhewnatoid arthritis M. NOBUNAGA and M. YASUDA DISEASE MODIFYING ANTI-RHEUMATIC DRUGS Mode of action of DMARDs Long-acting antirheumatic drugs induce differentiation of cells of the monocyte -macrophage lineage and alter the expression of cytoldnes and IL-1 receptor antagonist A.C. ALLISON and R.V. WATERS Methotrexate and Antimalarials Methotrexate: New mechanisms and old toxicities D.E. FURST Possible mechanisms of action of antimalarials in rheumatic disease D.J.CUTLER Insights from pharmacokinetic and pharmacodynamic studies of hydroxychloroquine S. TETT, A. MCLACHLAN, R.O. DAY and D.J. CUTLER Toxicity of antimalarial drugs in rheumatoid arthritis R.I. RYNES DMARDs: New and Old Tenidap: A new antiarthritic agent P.M. BROOKS Immunosuppressive and other anti-rheumatic activities of mycophenolate mycophenolate A.C. ALLISON and E.M. EUGUI Antioxidants as anti-rheumatics M.J. PARNHAM and D.R. BLAKE Sulphasalazine in rheumatic diseases M-DOUGADOS Variability in response to D-penicillamine: pharmacokinetic insights D.A. JOYCE Medicinal chemistry of gold G.G. GRAHAM, J.B. ZIEGLER and G.D. CHAMPION Comparative effects of gold on the interactions of transcription factors with DNA M.L. HANDEL, S. SIVERTSEN, C.K.W. WATTS, R.O. DAY and R.L. SUTHERLAND. SUBJECT INDEX.