Prenatal Diagnosis and Screening

SECTION I GENETIC COUNSELLING: Genetic Counselling and the Pre-Pregnancy Clinic SEC TION II FETAL SAMPLING TECHNIQUES: Amniocentesis. Chronic Villus Sampling. Fetal Blood and Tissue Sampling SECTION III VISAUALIZATION TECHNIQUES: Radiology and Magnetic Visulazition Techniques. Ultrasound Imaging Techniques SECTION IV LABORATORY TECHNIQUES: Cell Culture. Karyotype Analysis and Chromosome Disorders. Enzyme Analysis. Molecular Genetics. Alphafetoprotein and Acetylocholinesterase SECTION V CONGENITAL MALFORMATIONS: Incidence and Genetics of Congenital Malformations. Craniospinal Defects. Gastrointestinal and Abdominal Wall Tract Defects. Renal and Urinary Tract Abnormalities. Congenital Heart Disease. Skeletal Dysplasias. Dysmorphology Syndromes. Hydrops and Accociated Abnormalities SECTION VI CHROMOSOME ABNORMALITIES: Prevalance, Risks and Recurrence. Fragile X Syndrome. Chromosome Breakage Disorders SECTION VII MENDELIAN DISORDERS: Haemoglobinpathies. Cystic Fibrosis. Muscular Dystrophies. Haemophilias. Huntington's Disease and Other Late-Onset Autosomal Dominants. Immunodeficiency Diseases. Genodermatoses. Diagnosable Mendelian Disorders SECTION VIII DETERMINATION of ZYGOSITY and PATERNITY: Determination of Paternity and Twin Zygosity SECTION IX PRENATAL SCREENING: Biochemical Screening. Genetic Screening. Ultrasound Screening for Fetal Abnormalities. Screening as Public Policy SECTION X FUTURE TRENDS: Preimplantation Diagnosis. A Comprehensive Review. The Potential of Molecular Cytogenetics. Fetal Nucleated Cells in the Maternal Circulation SECTION XI MANAGEMENT of FETAL ABNORMALITY: Psychological Implications of Prenatal Diagnosis for Patients and Health Professionals. Pregnancy Termination. Selective Termination. Professional Understanding and Parents' Experiences of Termination. Fetal Therapy. Post-Mortem Examination SECTION XII SOCIAL ASPECTS: Ethical and Prenatal Diagnsosis: Past, Present and Future. Medicolegal Aspects. UK/ Europe. Medicolegal Aspects. USA Index