The Scid Mouse

I. General Phenotype/Cellular Characterization.- The scid Mutation: Occurrence and Effect.- Pleiotropic Effects of the scid Mutation: Effects on Lymphoid Differentiation and on Repair of Radiation Damage.- Analysis of Lymphoid Population in Scid Mice; Detection of a Potential B Lymphocyte Progenitor Population Present at Normal Levels in Scid Mice by Three Color Flow Cytometry With B220 and S7.- Phenotype and Differentiation Stage of Scid Mouse Thymocytes.- Growth Requirements of B Lineage Lymphocytes From Scid and Normal Mice.- Defect of Scid Mouse Revealed in In Vitro Culture Systems.- Natural Killer Cells and Their Precursors in Mice With Severe Combined Immunodeficiency.- II. General Phenotype/Molecular Characterization.- Nature of the scid Defect: A Defective VDJ Recombinase System.- Rearrangement of T Cell Receptor Delta Genes in Thymus of Scid Mice.- Abnormal V(D)J Recombination in Murine Severe Combined Immune Deficiency: Absence of Coding Joints and Formation of Alternative Products.- The scid Mutation Disrupts Gene Rearrangement at the Rejoining of Coding Strands.- The Effect of the scid Mutation on Mechanism and Control of Immunoglobulin Heavy and Light Chain Gene Rearrangement.- III. Introduction of Functional Ig or TCR Transgenes.- The Utilization of the scid Mutation in the Study of T Cell Development.- Transgenic Scid Mice With a Functionally Rearranged Immunoglobulin Heavy Chain Gene.- IV. Leaky Phenotypes.- T Cell Leakiness in Scid Mice.- Limited Clonal Diversity of Serum Immunoglobulin in Leaky Scid Mice.- Pauciclonal B Cell Involvement in Production of Immunoglobulin in Scid Ig+ Mice.- V. Potential Uses: Engraftment with Syngeneic Mouse Cells.- Reconstitution of Scid Mice by Injection of Varying Numbers of Normal Fetal Liver Cells into Scid Neonates.- Reconstitution of Lymphocyte Subsets in Scid Mice by Transplantation of Fetal Primordia.- Use of the Scid Mouse Tranplantation System in Studies of Lymphocyte Differentiation.- The Scid Mouse as a Model to Identify and Quantify Myeloid and Lymphoid Stem Cells.- VI. Potential Uses: Engraftment with Human Tissues and Cells.- The Scid-hu Mouse: Current Status and Potential Applications.- Studies of HIV Infection and the Development of Epstein-Barr Virus-Related B Cell Lymphomas Following Transfer of Human Lymphocytes to Mice With Severe Combined Immunodeficiency.- Human Lung Tumors, Patients' Peripheral Blood Lymphocytes and Tumor Infiltrating Lymphocytes Propagated in Scid Mice.- Adoptive Transfer of Human Peripheral Blood Lymphocytes (PBL) in Scid Mice.- Establishment of Assays for Human Hematopoietic Cells in Immune Deficient Mice.- VII. Potential Uses: Model For Studies of Immune Function.- Scid Mice in Reproductive Biology.- T Cell-Independent Macrophage Activation in Scid Mice.- Pneumocystis carinii Pneumonia in scid/scid Mice.- Immunobiology of Bone Marrow Transplantation: Studies Using Scid Mice.- Growth of Human Tumors in Immune-Deficient scid Mice and nude Mice.