BetaSys
Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
Published on 19. April 2013
Book
Paperback/Softback
XX, 556 pages
978-1-4614-2815-2 (ISBN)
Description
BetaSys uses the example of regulated exocytosis in pancreatic ß-cells, and its relevance to diabetes, to illustrate the major concepts of systems biology, its methods and applications.
Reviews / Votes
From the reviews:
"This second volume is Springer's Systems Biology series focuses on the organisation of pancreatic insulin-producing beta cells, with a particular focus on the technological approaches deemed necessary to further our understanding of beta cell physiology and the pathogenesis of diabetes. . I warmly recommend should be on the shelves of all research laboratories involved in modern beta cell research." (P. Meda, Diabetologia, Vol. 54, 2011)More details
Series
Edition
2011 ed.
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Research
Illustrations
XX, 556 p.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 31 mm
Weight
861 gr
ISBN-13
978-1-4614-2815-2 (9781461428152)
DOI
10.1007/978-1-4419-6956-9
Schweitzer Classification
Other editions
Additional editions
Bernhelm Booß-Bavnbek | Beate Klösgen | Jesper Larsen
BetaSys
Systems Biology of Regulated Exocytosis in Pancreatic ß-Cells
Book
03/2011
Springer
€213.99
Shipment within 15-20 days
Content
Preface.- Systems biology of ß-cells - revisited.- Established facts and open questions of the focused systems analysis of regulated exocytosis in ß-cells - a background for a focused systems analysis approach.- Mitochondria and metabolic signals in ß-cells.- ß-cell ontogenesis and the insulin production apparatus.- The role of the cytoskeleton in transport and release of the insulin-containing granules by pancreatic ß-cells.- The mathematical microscope making the inaccessible accessible.- Magnetic resonance imaging of pancreatic ß-cells.- Mapping the ß-cell in 3D at the nanoscale using novel cellular electron tomography and computational approaches.- In vivo applications of inorganic nanoparticles.- Cell cultivation and sensor-based assays for dynamic measurements of cell vitality: basic concepts.- Bioimpedance spectroscopy.- DNA variations, impaired insulin secretion and type-2 diabetes.- Genetically programmed defects in ß-cell function.- Proteomic analysis of the pancreatic islet ß-cell secretory granule: current understanding and future opportunities.- Physiological and pathophysiological role of islet amyloid polypeptide (IAPP, amylin) - a role in the pathogenesis of type-2 diabetes.- Present state of islet transplantation for type-1 diabetes patients.- Predictive protein networks and identification of drugable targets in the ß-cell.- Nanotoxicity.- From silicon cell to silicon human.- Probing cellular dynamics with mesoscopic simulations.- What drives calcium oscillations in ß-cells? new tasks for cyclic analysis.- Whole-body and cellular models of glucose-stimulated insulin secretion.- Geometric and electromagnetic aspects of fusion pore making.- Index.