Interaction of Nanomaterials with the Immune System
Published on 31. January 2021
Book
Paperback/Softback
X, 223 pages
978-3-030-33964-7 (ISBN)
Description
This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma.
Interaction of Nanomaterials with the Immune System
covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.
More details
Series
Edition
2020 ed.
Language
English
Place of publication
Cham
Switzerland
Publishing group
Springer International Publishing
Target group
Professional and scholarly
Illustrations
11 s/w Abbildungen, 5 farbige Abbildungen
X, 223 p. 16 illus., 5 illus. in color.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 13 mm
Weight
365 gr
ISBN-13
978-3-030-33964-7 (9783030339647)
DOI
10.1007/978-3-030-33962-3
Schweitzer Classification
Other editions
Additional editions
James C. Bonner | Jared M. Brown
Interaction of Nanomaterials with the Immune System
Book
01/2020
Springer
€160.49
Shipment within 7-9 days
Persons
James C. Bonner is Professor of Toxicology at North Carolina State University. His research focuses on the fibroproliferative effects of nanomaterials in the lung, particularly in susceptible disease models.
Jared M. Brown is Professor of Toxicology at the University of Colorado Anschutz Medical Campus. His research focuses on allergic immune responses to nanomaterials and their application in medicine.
Jared M. Brown is Professor of Toxicology at the University of Colorado Anschutz Medical Campus. His research focuses on allergic immune responses to nanomaterials and their application in medicine.
Content
Overview of immune response to nanomaterials caused by either inhalation, oral, or dermal exposure.- Engineered nanomaterials: synthesis, characterization, uses and exposure.- Impact of nanomaterials on barrier function.- Complement activation and inflammation.- Macrophage function and phagocytosis.- Mast cells.- Impact on dendritic cell - lymphocyte function.- Impact on host pathogen response and microbiome.- Allergy/autoimmunity.- Pre-existing allergic or bacterial-induced lung disease.- Nanomaterial effects on viral infection.- Immunotoxicity and carcinogenesis.- In vivo animal models (nude mice, transgenic models).- In vitro cell culture models.- In silico computational modeling.- Summary of mechanisms of immune modulation.