The Practice of Peptide Synthesis
2nd Edition
Published on 30. August 1994
Book
Paperback/Softback
XVIII, 217 pages
978-3-540-57505-4 (ISBN)
Description
During the years 1980-81, as guests of the Deutsches Wollforschungsinstitut in Aachen, Germany, we were working on a small book entitled, "Principles of Peptide Synthesis". In the library of the Institute we noted that the volumes of Houben-Weyl's Handbuch der Organischen Chemie dealing with peptide synthesis were so much in use that they were ready to fall apart because the researchers of the Institute consulted them with amazing regularity. They were looking for references, but even more for experimental details which could be adapted to the particular problem they happened to face. In planning a new synthetic endeavor they tried to lean on the experience of others in analogous situations. This suggested to us that a smaller and hence more tractable book may be needed, a volume which can be kept on or near the bench to make examples of fundamental methods readily available in the laboratory. Such a collection could save numerous short trips to the library, a point particularly important where a library well equipped with the sources of the literature of peptide synthesis is not near at hand. Also, we thought that the envisaged book may be welcome by those who are more versed in English than in German. To the best of our knowledge no similar publication is available.
More details
Series
Edition
Second Edition 1994
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Professional/practitioner
Illustrations
41 s/w Abbildungen
XVIII, 217 p. 41 illus.
Dimensions
Height: 242 mm
Width: 193 mm
Thickness: 13 mm
Weight
467 gr
ISBN-13
978-3-540-57505-4 (9783540575054)
DOI
10.1007/978-3-642-85055-4
Schweitzer Classification
Other editions
Additional editions
Miklos Bodanszky | Agnes Bodanszky
The Practice of Peptide Synthesis
E-Book
12/2012
2nd Edition
Springer
€96.29
Available for download
Previous edition
Miklos Bodanszky | Agnes Bodanszky
The Practice of Peptide Synthesis
Book
11/1984
1st Edition
Springer
€85.55
Article exhausted; check for reprint
Content
I Introduction.- II Protecting Groups.- 1 Introduction of Amine Protecting Groups.- 2 Blocking of the ?-Carboxyl Group.- 3 Protection of Side Chain Functions.- III Activation and Coupling.- 1 The Acid Chloride Procedure.- 2 The Azide Process.- 3 Symmetrical Anhydrides.- 4 Mixed Anhydrides.- 5 Preparation of Active Esters.- 6 Coupling with Active Esters.- 7 Peptide Bond Formation with the Aid of Coupling Reagents.- IV Removal of Protecting Groups.- 1 Hydrogenation.- 2 Reduction with Sodium in Liquid Ammonia.- 3 Removal of the Phthalyl (Phthaloyl) Group by Hydrazinolysis.- 4 Acidolysis.- 5 Hydrolysis.- 6 Base Catalyzed Elimination.- 7 Nucleophilic Displacement.- 8 Iodolysis.- 9 Reduction of Methionine Sulfoxide Containing Peptides.- V Special Procedures.- 1 Ammonolysis of Esters.- 2 Transesterification.- 3 Cyclization.- 4 Polycondensation.- 5 Partial Synthesis.- VI Models for the Study of Racemization.- 1 Benzoyl-leucyl-glycine Ethyl Ester.- 2 The Anderson-Callahan Test.- 3 Acylation with Acetyl-l-isoleucine.- 4 The Izumiya-Muraoka Model.- 5 Synthesis and Enantioselective Enzymic Hydrolysis of Tetraalanine.- VII Reagents for Peptide Synthesis.- 1 tert-Butyl Azidoformate.- 2 1-Adamantyl Chlorocarbonate.- 3 1-Isobutyloxycarbonyl-2-isobutyloxy-1,2-dihydroquinoline (IIDQ).- 4 Diphenyl Phosphorazidate (Diphenylphosphoryl Azide, DPPA).- 5 3-Hydroxy-3,4-dihydroquinazoline-4-one (4-Hydroxyquinazoline 3-oxide).- 6 1-Hydroxybenzotriazole.- 7 Ethyl 2-hydroximino-2-cyanoacetate.- 8 1-Guanyl-3,5-dimethyl-pyrazole Nitrate.- VIII Appendix.- 1 Conversion of Dicyclohexylammonium Salts of Protected Amino Acids to the Free Acids.- 2 Preparation pf Analytical Samples.