Nucleic Acids
Structure, Properties, and Functions
Published on 17. April 2000
Book
Hardback
672 pages
978-0-935702-49-1 (ISBN)
Description
This is a comprehensive and up-to-date account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function. The book has been carefully organised to meet the needs of molecular biologists, physical biochemists and physical chemists with only a basic understanding of physical chemistry and molecular biology. Nucleic Acids will serve as a textbook in physical biochemistry and biophysical chemistry classes, as well as a supplemental text in courses on nucleic acid biochemistry or molecular biology, and as a personal reference for students and researchers in these fields.
More details
Persons
VICTOR A. BLOOMFIELD, University of Minnesota
DONALD M. CROTHERS, Yale University
IGNACIO TINOCO, University of California, Berkeley
DONALD M. CROTHERS, Yale University
IGNACIO TINOCO, University of California, Berkeley
Content
Introduction.- Bases, Nucleosides and Nucleotides.- Chemical and Enzymatic Methods.- Nucleic Acid Structures from Diffraction Methods.- Structure and Dynamics by NMR.- Electronic and Vibrational Spectroscopy.- Theoretical Methods.- Conformational Changes.- Size and Shape of Nucleic Acids in Solution.- Supercoiled DNA.- Interaction of Nucleic Acids with Water and Ions.- Interaction and Reaction with Drugs.- Protein-Nucleic Acid Interactions.- Higher Order Structure.- Index.