Regulatory Function of Adenosine

I. Adenosine Receptors.- 1. The complex structure and regulation of adenylate cyclase.- 2. Adenosine receptors and adenylate cyclase interactions.- 3. Adenosine receptors on vascular smooth muscle.- 4. A comparison of receptors for adenosine and adenine nucleotides.- 5. General aspects of ligand-binding phenomena.- 6. General aspects of binding of ligands to adenosine receptors.- 7. Binding of radioactive ligands to adenosine receptors in the central nervous system.- II. Adenosine Metabolism and Transport.- 8. Regulation of adenosine metabolism by 5?-nucleotidases.- 9. Metabolism of adenosine and sites of production in the heart.- 10. Interaction of adenosine with adenosine-binding protein, S-adenosylhomocysteine hydrolase.- 11. S-Adenosylhomocysteine hydrolase as a target in genetic and drug-induced deficiency of adenosine deaminase.- 12. Nucleoside transport in mammalian cells and interaction with intracellular metabolism.- 13. Inhibition of nucleoside transport.- III. Adenosine and Regulation of Immune Function.- 14. Mechanisms of toxicity of adenosine, 2-deoxyadenosine, and inhibitors of adenosine deaminase.- 15. Clinical expression of blocks of purine nucleotide degradation.- 16. Adenosine and cyclic nucleotides in modulation of immune responses.- 17. Mechanisms of adenosine and 2? -deoxyadenosine inhibition of immune function in mouse lymphocytes.- IV. Adenosine and Platelet Function.- 18. Receptors for nucleosides and nucleotides on blood platelets.- V. Vascular Effects of Adenosine.- 19. Blood flow regulation by adenosine in heart, brain, and skeletal muscle.- 20. Mechanisms of action of adenosine on vascular smooth muscle and cardiac cells.- 21. Adenosine uptake and adenine nucleotide metabolism by vascular endothelium.- 22. Adenine nucleotide and adenosinemetabolism in cultured coronary endothelial cells: formation and release of adenine compounds and possible functional implications.- VI. Influence of Adenosine on Cardiac and Renal Function.- 23. Antiadrenergic effects of adenosine in the heart.- 24. Chronotropic and dromotropic effects of adenosine.- 25. Adenosine and renal function.- VII. Actions of Adenosine in the Nervous System.- 26. The role of adenosine in central neuromodulation.- 27. Synaptic modulation by adenosine: electro physiological and biochemical characteristics.- 28. Modulation of calcium currents by adenosine receptors on mammalian sympathetic neurons.- 29. Interactions of adenosine with other agents.- 30. Adenosine in the regulation of neurotransmitter release in the peripheral nervous system.- Abstracts.