Susceptibility to Infectious Diseases
The Importance of Host Genetics
Published on 4. February 2010
Book
Paperback/Softback
424 pages
978-0-521-12959-6 (ISBN)
Description
In the last fifteen years, substantial progress has been made in identifying why some people are particularly susceptible to specific infectious diseases. Extensive evidence has accumulated that host genes are important determinants of the outcome of infection for many common pathogens. This book summarises advances that have been made in understanding the complexity of host genetic susceptibility. The diseases covered include those of great public health importance such as malaria and HIV, and those of topical interest such as Creutzfeldt-Jakob disease. Many different techniques have been used to identify host genes involved in infectious disease susceptibility. Each chapter describes how these discoveries were made and the book is therefore useful to anyone planning genetic studies on a multi-factorial disease, regardless of whether it has an infectious etiology.
More details
Series
Language
English
Place of publication
Cambridge
United Kingdom
Target group
Professional and scholarly
Product notice
Paperback (trade)
Illustrations
Worked examples or Exercises
Dimensions
Height: 229 mm
Width: 152 mm
Thickness: 25 mm
Weight
685 gr
ISBN-13
978-0-521-12959-6 (9780521129596)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
Additional editions
E-Book
05/2006
1st Edition
Cambridge University Press
€38.49
Available for download
Book
12/2003
Cambridge University Press
€154.99
Article exhausted; check for reprint
Previous edition
Book
12/2003
Cambridge University Press
€154.99
Article exhausted; check for reprint
Person
Content
1. Introduction Richard Bellamy; 2. Application of genetic epidemiology to dissecting host susceptibility/resistance to infection illustrated with the study of common mycobacterial infections Alexandre Alcais and Laurent Abel; 3. The diverse genetic basis of immunodeficiencies Mauno Vihinen; 4. Genetic diversity in the major histocompatibility complex and the immune response to infectious diseases Leland J. Yee and Mark R. Thursz; 5. The cystic fibrosis transmembrane conductance regulator Alan W. Cuthbert; 6. The influence of inherited traits on malaria infection David J. Roberts, Tyler Harris and Thomas Williams; 7. Polymorphic chemokine receptor and ligand genes in HIV infection Jianming (James) Tang and Richard A. Kaslow; 8. N-ramp and resistance in intracellular pathogens Philippe Gros and Erwin Schurr; 9. The interleukin-12-interferon-? loop is required for protective immunity to experimental and natural infections by mycobacterium Marion Bonnet, Claire Soudais and Jean-Laurent Casanova; 10. Mannose-binding lectin deficiency and susceptibility to infectious disease Dominic L. Jack, Nigel J. Klein and Malcolm W. Turner; 11. Blood group phenotypes and infectious diseases C. Caroline Blackwell, Donald M. Weir, Abdulhamid M. Alkout, Omar R. El Ahmer, Doris A. C. Mackenzie, Valerie S. James, J. Matthias Braun, Osama M. Almadani and Anthony Busuttil; 12. Genetics of human susceptibility to infection and hepatic disease caused by schistosomes Alain J. Dessein, Nasureldin El Wali, Sandrine Marquet, Laurent Abel, Virmondes Rodrigues Jr., Carole Eboumbou Moukoko, Helia Dessein, Laurent Argiro, Sandrine Henri, Dominique Hillaire, Gachuhi Kimani, Aluizio Prata, Mubarak Magzoub and Christophe Chevillard; 13. Genetic susceptibility to prion diseases Matthew Bishop and J. W. Ironside.