T.Cell Receptors
Published on 31. October 1995
Book
Paperback/Softback
503 pages
978-0-19-262419-2 (ISBN)
Description
T cell receptors covers biochemical, functional and genetic aspects of this key family of immunological molecules. It should be essential reading for all those interested in the TCR and its function in health and disease. It deals with the TCR protein, its functional interactions with the signal transduction machinery of the T cell and with the structure and organisation of the TCR genes. It is the only comprehensive volume on the TCR and is written by leaders in the field. Particularly useful is the tabulation and nomenclature of all the known TCR alpha and beta variable regions. This book is intended for any specialist researcher interested in T cells. All postgraduate immunologists.
More details
Language
English
Place of publication
Oxford
United Kingdom
Target group
College/higher education
Professional and scholarly
Illustrations
6 colour plates; halftones, line figures, tables, bibliography
Dimensions
Height: 230 mm
Width: 150 mm
Weight
760 gr
ISBN-13
978-0-19-262419-2 (9780192624192)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Persons
Content
Introduction: Historical overview. 1: Development of T cells in the thymus. 2: The function of aBT cells and the role of the co-receptor molecule, CD4 and CD8. 3: T cell specificity and function. 4: Emergence of the T cell receptor repertoire. 5: The human T cell receptor repertoire. 6: T cell activation. 7: Transgenesis and the T cell receptor. 8: Superantigens and tolerance. 9: Src - related kinases and their receptors in T cell activation. 10: Organisation of the human TCRB gene complex. 11: Genomic organisation of T cell receptor genes in the mouse. 12: Nature of variation among variable genes. 13: T cell receptor V(D)J recombination: Mechanisms and developmental regulation. 14: Allelic exclusion of T cell antigen receptor genes. 15: Plasticity of the TCR/CD3 complex. 16: The immune recognition unit: The TCR/peptide/MHC complex. 17: A structural model of a bacterial superantigen binding to MHC class II and T cell receptors. 18: Biosynthesis of MHC products and its relevance for antigen presentation. Appendix A1 - Nomanclative. Appendix A2 - Sequences