T.Cell Receptors
Published on 1. October 1995
Book
Paperback/Softback
503 pages
978-0-19-262418-5 (ISBN)
Description
The T cell receptor is the structure on T lymphocytes that recognises cell bound antigen in association with MHC class I or class II antigens. This book covers biochemical, functional and genetics aspects of this key immunological molecule.
More details
Language
English
Place of publication
Oxford
United Kingdom
Target group
College/higher education
Professional and scholarly
Illustrations
bibliography
ISBN-13
978-0-19-262418-5 (9780192624185)
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Schweitzer Classification
Persons
Content
Historical overview; Development of T cells in the thymus; The function of aBT cells and the role of the co-receptor molecule, CD4 and CD8; T cell specificity and function; Emergence of the T cell receptor repertoire; The human T cell receptor repertoire; T cell activation; Transgenesis and the T cell receptor; Superantigens and tolerance; SRC - related kinases and their receptors in T cell activation; Organization of the human TCRB gene complex; Genomic organization of T cell receptor genes in the mouse; Nature of variation among variable genes; T cell receptor V(D)J recombination: Mechanisms and developmental regulation; Allelic exclusion of T cell antigen receptor genes; Plasticity of the TCR/CD3 complex; The immune recognition unit: The TCR/peptide/MHC complex; A structural model of a bacterial superantigen binding to MHC class II and T cell receptors; Biosynthesis of MHC products and its relevance for antigen presentation.