Proteinase Inhibitors
Published in October 1986
Book
Hardback
684 pages
978-0-444-80763-2 (ISBN)
Description
The twelfth volume in this well established series presents the latest research on proteinases, which are known or suspected to be implicated in many aspects of normal physiology and disease processes. In order to understand the nature of this involvement the researcher must repeatedly resort to our current understanding of proteinase inhibitors. The chapters in this book cover various approaches to the investigation and treatment of a wide variety of medical problems, including malignancy, arthritis, hypertension and coagulation disorders, viral, bacterial and parasitic infections, muscular dystrophy, pulmonary emphysema and neurological disease. Due to the level of sophistication of naturally occurring protein inhibitors, techniques such as X-ray crystallography are being used intensively, and the results are being fed back into the design of artificial inhibitors made chemically or by genetic engineering. Rapid technical progress in these synthetic methods encourages the full use of new information available, and the outcome is that a range of new drugs are in the stage of pre-clinical trials.
The twelfth volume in this well established series presents the latest research on proteinases, which are known or suspected to be implicated in many aspects of normal physiology and disease processes. In order to understand the nature of this involvement the researcher must repeatedly resort to our current understanding of proteinase inhibitors. The chapters in this book cover various approaches to the investigation and treatment of a wide variety of medical problems, including malignancy, arthritis, hypertension and coagulation disorders, viral, bacterial and parasitic infections, muscular dystrophy, pulmonary emphysema and neurological disease. Due to the level of sophistication of naturally occurring protein inhibitors, techniques such as X-ray crystallography are being used intensively, and the results are being fed back into the design of artificial inhibitors made chemically or by genetic engineering. Rapid technical progress in these synthetic methods encourages the full use of new information available, and the outcome is that a range of new drugs are in the stage of pre-clinical trials.
The twelfth volume in this well established series presents the latest research on proteinases, which are known or suspected to be implicated in many aspects of normal physiology and disease processes. In order to understand the nature of this involvement the researcher must repeatedly resort to our current understanding of proteinase inhibitors. The chapters in this book cover various approaches to the investigation and treatment of a wide variety of medical problems, including malignancy, arthritis, hypertension and coagulation disorders, viral, bacterial and parasitic infections, muscular dystrophy, pulmonary emphysema and neurological disease. Due to the level of sophistication of naturally occurring protein inhibitors, techniques such as X-ray crystallography are being used intensively, and the results are being fed back into the design of artificial inhibitors made chemically or by genetic engineering. Rapid technical progress in these synthetic methods encourages the full use of new information available, and the outcome is that a range of new drugs are in the stage of pre-clinical trials.
More details
Series
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
College/higher education
Professional and scholarly
Dimensions
Height: 230 mm
Width: 150 mm
ISBN-13
978-0-444-80763-2 (9780444807632)
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Schweitzer Classification
Content
Preface. List of Contributors. Section A. Introductory Chapters . 1. An introduction to the proteinases by A.J. Barrett. 2. The characterization of enzyme inhibition by C.G. Knight. Section B. Synthetic and Related Inhibitors . 3. Inhibitors of serine proteinases by J.C. Powers and J.W. Harper. 4. Inhibitors of cysteine proteinases by D.H. Rich. 5. Inhibitors of aspartic proteinases by D.H. Rich. 6. Inhibitors of metalloproteinases by J.C. Powers and J.W. Harper. Section C. Protein Inhibitors . 7. Introduction to the protein inhibitors: X-ray crystallography by R.J. Read and M.N.G. James. 8. Proteinase inhibitors of the leech hirudo medicinalis (hirudins, bdellins, eglins) by U. Seemuller et al. 9. Bowman-Birk family serine proteinase inhibitors by T. Ikenaka and S. Norioka. 10. Biochemistry of aprotinin and aprotinin-like inhibitors by W. Gebhard et al. 11. Inter-a-trypsin inhibitor and its close relatives by W. Gebhard and K. Hochstrasser. 12. Serpins: the superfamily of plasma serine proteinase inhibitors by R.W. Carrell and D.R. Boswell. 13. Molecular analysis of the serine proteinase inhibitor gene family by V.J. Kidd and S.L.C. Woo. 14. Human a 1 -proteinase inhibitor by H. Heidtmann and J. Travis. 15. a 2 -Antiplasmin by H.R. Lijnen and D. Collen. 16. Human C1-inhibitor by B. Wiman. 17. Antithrombina and related inhibitors of coagulation proteinases by I. Bjork and A. Danielsson. 18. Cysteine proteinase inhibitors of the cystatin superfamily by A.J. Barrett et al. 19. Calpastatins by C. Parkes. 20. Protein inhibitors of metallo-proteinases by T.E. Cawston. Section D. Biological Aspects . 21. Proteinase inhibitors as drugs by H.-P. Schnebli and N.J. Braun. Subject Index.