
The Cytokine Network
Fran Balkwill(Editor)
Oxford University Press
Published on 10. February 2000
Book
Paperback/Softback
216 pages
978-0-19-963702-7 (ISBN)
Description
Cytokines are soluble mediators of intercellular communication. They contribute to a chemical signalling language that regulates development, tissue repair, haemopoiesis, inflammation and the immune response. Potent cytokine polypepides have pleiotropic activities and functional redundancy. They act in a complex network where one cytokine can influence the production of, and response to, many other cytokines. In the past five years, this bewildering array of more than 100 effector molecules and associated cell surface receptors has been simplified by study of cytokine and cytokine receptor structure; elucidation of convergent intracellular signalling pathways; and molecular genetics, and targeted gene disruption to 'knock-out' production of individual cytokines in mice. It is also now clear that the pathophysiology of infectious, autoimmune and malignant disease can be partially explained by the induction of cytokines and the subsequent cellular response. Viral homologues exist for many cytokines and receptors and genetic variations in cytokine production may influence response to pathogenic stimuli. Cytokine and cytokine antagonists have shown therapeutic potential in a number of chronic and acute diseases. The Cytokine Network: Frontiers in Molecular Biology is not a survey of individual cytokines, but guides the reader through the latest research on the cytokine network as a whole covering genomics, signalling pathways, control of the immune response, and therapeutics.
Reviews / Votes
" ... it is well written with up to date references throughout ... I would recommend the book to those that want a comprehensive look into the detailed interactions of cytokines and especially in the role they may play in disease." Immunology News '... a useful introductory text for biologists entering the complex field of cytokine research' Cell Biology InternationalMore details
Series
Language
English
Place of publication
Oxford
United Kingdom
Target group
College/higher education
Professional and scholarly
Illustrations
line figures
Dimensions
Height: 245 mm
Width: 188 mm
Thickness: 13 mm
Weight
476 gr
ISBN-13
978-0-19-963702-7 (9780199637027)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Person
Content
Preface ; A Genomics Approach to Cytokine Discovery ; Cytokine Signal Transduction ; Cytokine and the Th1/Th2 Paradigm ; Chemokines ; Cytokines and Cytokine Receptors Encoded by Viruses ; Genetic Variation in Cytokines and Relevance to Inflammation and Disease ; Therapeutic Manipulation of the Cytokine Network ; Index