Organ-Selective Actions of Steroid Hormones
Published on 23. August 2014
Book
Paperback/Softback
XIV, 184 pages
978-3-662-09155-5 (ISBN)
Description
Steroids regulate differentiation, growth and functioning of many tissues via a nuclear receptor gene activation mechanism. Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading experts address basic molecular mechanisms of tissue specificity and related issue, with the goal of attaining a better understanding of the underlying mechanisms of organ selective actions of steroids. Discussed is the extent to which tissue specificity might selectively be modified by chemical modification of the hormones and how this may be applied towards improved therapies by taking advantage of tissue selectivity.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1995
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Professional/practitioner
Illustrations
38 s/w Abbildungen
XIV, 184 p. 38 illus.
Dimensions
Height: 235 mm
Width: 155 mm
Thickness: 12 mm
Weight
312 gr
ISBN-13
978-3-662-09155-5 (9783662091555)
DOI
10.1007/978-3-662-09153-1
Schweitzer Classification
Other editions
Additional editions
D.T. Baird | G. Schütz | R. Krattenmacher
Organ-Selective Actions of Steroid Hormones
E-Book
03/2013
Springer
€53.49
Available for download
D.T. Baird | G. Schütz | R. Krattenmacher
Organ-Selective Actions of Steroid Hormones
Book
11/1995
Springer
€85.59
Article exhausted; check different version
Content
1 Development of Tissue-Selective Estrogen Receptor Modulators.- 2 Estrogen-Receptor and Antiestrogen-Receptor Complexes: Cell- and Promoter-Specific Effects and Interactions with Second Messenger Signaling Pathways.- 3 Analysis of Genetically Altered Mice Without Glucocorticoid Receptor.- 4 Organ-Selective Actions of Tamoxifen and Other Partial Antiestrogens.- 5 Progestin Regulation of Cell Proliferation in the Breast and Endometrium.- 6 Central Versus Endometrial Effects of Antiprogestins: Is Endometrial Selectivity Possible?.- 7 Androgen Action on the Bone.- 8 General Principles of Vitamin D Action and Mechanism-Based Search for Analogs with Specific Actions.- 9 Organ-Specific Actions of Vitamin D Analogs: Relevance of Rapid Effects.- Previous Volumes Published in this Series.