Extracellular Fine Particles
Description
This open access book elucidates new biological phenomena caused by extracellular fine particles and highlights the development of base technologies for their control. In this book, the latest knowledge is collected on the principles of extracellular fine particles recognition, action, and biological responses. In addition, the base technologies for their detection, separation, measurement, and analysis are discussed. It also presents the treatment of endogenous and exogenous fine particles and analytical methods as well as functions of extracellular fine particles. This book is useful for undergraduate and graduate students engaged in research on extracellular fine particles, academic and corporate researchers, as well as national think tanks and national policy makers to understand the basics and applications of extracellular microparticles.
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Persons
Dr. Yoshinobu Baba received Ph.D. degree in 1986 from Kyushu University. He is now a director general of Institute for Quantum Life Science, National Institutes for Quantum Science and Technology(QST). He is also a designated professor of Institutes of Innovation for Future Society, Nagoya University, and a research supervisor, JST CREST Extracellular Fine Particles Project. He has been admitted as a fellow of the Royal Society of Chemistry and received over 90 awards, prizes, and Medal for his contributions in nanobioscience and quantum life science, including the Medal with Purple Ribbon, the Commendation for Science and Technology by the Minister of Education, Science, and Technology, and the Chemical Society of Japan Award. Dr. Baba's research studies are directed to the development of nanobiodevices and quantum life science for omics, systems biology, medical diagnosis, tissue engineering, and molecular imaging.
Dr. Rikinari Hanayama received M.D. and Ph.D. degrees from Osaka University in 2004 for his research on phagocytosis of apoptotic cells. He was a HFSP fellow at Harvard Medical School and an assistant professor at Kyoto University before starting his own laboratory as an associate professor at WPI Immunology Frontier Research Center (IFReC) at Osaka University in 2011, where he began research on extracellular vesicles. In 2015, he moved to Kanazawa University, where he is a professor at the School of Medicine and WPI Nano Life Science Institute (NanoLSI). His research aims to elucidate the functions of extracellular vesicles in immunity, cancer progression, and neurodegeneration, and to develop new drugs using extracellular vesicles.
Dr. Hidetaka Akita received Ph.D. degree in 2002 from the University of Tokyo. He is a professor of Graduate School of Pharmaceutical Sciences at Tohoku University. He has received many awards regarding drug delivery systems. His research interests are focused on drug delivery systems, immune engineering, and DNA/RNA vaccine.
Dr. Takao Yasui received Ph.D. degree in 2011 from Nagoya University. He is an associate professor at Department of Biomolecular Engineering, Graduate School of Engineering at Nagoya University, a PRESTO researcher at the Japan Science and Technology Agency (JST), and a co-founder and a Nanodevice Director at Craif Inc. He has received over 37 awards for his contributions in the field of oxide nanowire microfluidics. His research interests are focused on designing, fabricating, and characterizing oxide nanowire microfluidics for applications in healthcare, diagnosis, sensing biomolecules, and engineering biology.
Content
Extracellular fine fiber-induced carcinogenesis and its prevention.- Toward Digital Bioanalysis of Extracellular Vesicles.- Mechanisms of asymmetrical exosome release from polarized epithelial cells: implications for the molecular basis of exosomal heterogeneity.- Control of the particle trafficking and dynamics of the lymphatic system and of the cellular microenvironment.- Elucidation of the mechanisms that regulate the quantity and quality of exosomes un cancer.- Membrane dynamics of exosomes as revealed by sin-gle-molecule imaging.- Glycan remodeling by small extracellular vesicles.- Analysis of immune responses induced by inhaled fine particulates.- Harnessing DNA and Energy Cargo: Unveiling the Active Biogenesis and Applications of Bacterial Extracellular Vesicles.- Macropinocytosis and the related actin-driven cellular uptake pathways for extracellular fine particles.- Relationship between bio-distribution of environmental particles and induction of biological and immune response in the respiratory system.- Direct observation of biological fine particles in water by scanning electron assisted dielectric microscopy.- Pathways to repair or remove lysosomes damaged by extracellular fine particles.- Neurodegenerative disorder and fine particulate matter.- Extracellular vesicle isolation and analysis using nanowires.- Particulars of Oral Cavity.- High dimensional cytometry for studying heterogeneous small particles.- Magnetic nanoparticles for diagnostics and therapy.- Engineered and artificial exosomes for non-viral drug delivery nanocarriers.