Potassium Channels in Cardiovascular Biology

1 Evolution of Potassium Channel Proteins.- 2 Three-Dimensional Structure of the K+ Channel Pore: Basis for Ion Selectivity and Permeability.- 3 Molecular Biology of Voltage-Gated K+ Channels.- 4 Molecular Biology of High-Conductance, Ca2+-Activated Potassium Channels.- 5 Molecular Biology of Inward Rectifier and ATP-Sensitive Potassium Channels.- 6 Design and Use of Antibodies for Mapping K+ Channel Expression in the Cardiovascular System.- 7 Molecular Methods for Evaluation of K+ Channel Expression and Distribution in the Heart.- 8 Concepts for Patch-Clamp Recording of Whole-Cell and Single-Channel K+ Currents in Cardiac and Vascular Myocytes.- 9 The Patch-Clamp Technique for Measurement of K+ Channels in Xenopus Oocytes and Mammalian Expression Systems.- 10 Heteromultimer Formation in Native K+ Channels.- 11 Use of Transgenic and Gene-Targeted Mice to Study K+ Channel Function in the Cardiovascular System.- 12 Pharmacology of Voltage-Gated K+ Channels.- 13 Pharmacology of High-Conductance, Ca2+ -Activated Potassium Channels.- 14 Pharmacology of Small-Conductance, Calcium-Activated K+ Channels.- 15 Molecular Pharmacology of ATP-Sensitive K+ Channels: How and Why?.- 16 Overview: Molecular Physiology of Cardiac Potassium Channels.- 17 Molecular Mechanisms Controlling Functional Voltage-Gated K+ Channel Diversity and Expression in the Mammalian Heart.- 18 Voltage-Gated Potassium Channels in the Myocardium.- 19 Inward Rectifying and ATP-Sensitive K+ Channels in the Ventricular Myocardium.- 20 Cholinergic and Adrenergic Modulation of Cardiac K+ Channels.- 21 Cardiac K+ Channel Expression and Function at Birth and in the Neonate.- 22 Overview: Physiological Role of K+ Channels in the Regulation of Vascular Tone.- 23 Modulation of Vascular K+ Channels by Extracellular Messengers.- 24 Delayed Rectifier K+ Channels of Vascular Smooth Muscle: Characterization, Function, and Regulation by Phosphorylation.- 25 Potassium Channels in the Circulation of Skeletal Muscle.- 26 Regulation of Cerebral Artery Diameter by Potassium Channels.- 27 The Role of Potassium Channels in the Control of the Pulmonary Circulation.- 28 Potassium Channels in the Renal Circulation.- 29 Potassium Channels in the Coronary Circulation.- 30 Vascular K+ Channel Expression and Function at Birth and in the Neonate.- 31 Overview: Potassium Channels in Vascular Endothelial Cells.- 32 Single-Channel Properties of Ca2+-Activated K+ Channels in the Vascular Endothelium.- 33 Endothelial Cell K+ Channels, Membrane Potential, and the Release of Vasoactive Factors from the Vascular Endothelium.- 34 Activation of Vascular Smooth Muscle K+ Channels by Endothelium-Derived Factors.- 35 Overview: Role of Potassium Channels in Cardiac Arrthythmias.- 36 The Molecular Basis of the Long QT Syndrome.- 37 Altered K+ Channel Expression in the Hypertrophied and Failing Heart.- 38 Role of ATP-Sensitive K+ Channels in Cardiac Preconditioning.- 39 Therapeutic Potential of ATP-Sensitive K+ Channel Openers in Cardiac Ischemia.- 40 Altered Expression and Function of Kv Channels in Primary Pulmonary Hypertension.- 41 Anorectic Drugs and the Vasculature.- 42 Induction of Ca2+-Activated K+ Channel Expression during Systemic Hypertension: Protection against Pathological Vasoconstriction.- 43 Antisense Approaches and the Modulation of Potassium Channel Function in the Cardiovascular System.