
Current Topics in Microbiology and Immunology
Springer (Publisher)
Published on 15. November 2011
Book
Paperback/Softback
IV, 170 pages
978-3-642-67343-6 (ISBN)
Description
1.1 Classification of Togaviruses The family, Togaviridae, is composed of the alphaviruses, the flaviviruses, rubella (a rubivirus), and the pestiviruses (Fenner, 1976). Of these four genera, two (the alpha- and flaviviruses) are transmitted by blood-sucking arthropods, specif ically mosquitoes and ticks. Among the togaviruses, extensive studies of defective interfering (DI) particles have so far been carried out only with Sindbis virus (SV) and Semliki Forest virus (SFV), both members of the alphavirus genus. Since these viruses are so similar, in most cases it will be assumed that what is true of one is also true of the other. 1.2 Definition of Defective Interfering (DI) Particles Defective interfering viral particles, as defined by Huang (1973), have the follow ing properties: (1) they are deletion mutants and therefore lack large amounts of the genetic material present in the standard virus; (2) they contain the same viral structural proteins as standard virus; (3) they are unable to replicate alone; however, they are replicated in cells co-infected with standard virions; and (4) at the same time as they require standard virus to replicate, they inhibit the replication of standard virus and hence are interfering.
More details
Series
Edition
Softcover reprint of the original 1st ed. 1979
Language
English
Place of publication
Berlin
Germany
Publishing group
Springer Berlin
Target group
Professional and scholarly
Research
Illustrations
IV, 170 p.
Dimensions
Height: 244 mm
Width: 170 mm
Thickness: 11 mm
Weight
322 gr
ISBN-13
978-3-642-67343-6 (9783642673436)
DOI
10.1007/978-3-642-67341-2
Schweitzer Classification
Other editions
Additional editions

W. Arber | S. Falkow | W. Henle
Current Topics in Microbiology and Immunology: 86
Book
10/1979
1st Edition
Springer
€85.55
Article exhausted; check different version
Content
Genetic Potential of Bunyaviruses.- Defective Interfering Particles of Togaviruses.- The Fv-1 Gene of the Mouse and its Control of Murine Leukemia Virus Replication.- Defective Interfering Particles of Rhabdoviruses.- Indexed in Current Contents.