Practical Process Research and Development - A guide for Organic Chemists
Practical Process Research and Development - A guide for Organic Chemists
2nd Edition
Published on 15. April 2012
Book
Paperback/Softback
486 pages
978-1-4933-0125-6 (ISBN)
Description
Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry."
Second Edition highlights:
* Reflects the current thinking in chemical process R&D for small molecules
* Retains similar structure and orientation to the first edition.
* Contains approx. 85% new material
* Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)
* Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)
* Replaces the first edition, although the first edition contains useful older examples that readers may refer to
Second Edition highlights:
* Reflects the current thinking in chemical process R&D for small molecules
* Retains similar structure and orientation to the first edition.
* Contains approx. 85% new material
* Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up)
* Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes)
* Replaces the first edition, although the first edition contains useful older examples that readers may refer to
Reviews / Votes
"This second edition text is at a more advanced level than the original, reflecting the abundant sources of information that have become available in the last ten years and the author's reconsideration of this presentation. Anderson has worked for 30-plus years in the pharmaceutical industry. His text offers a step-by-step approach, beginning with discussion of how and why operations are carried out and then illustrating principles with examples. Coverage encompasses process safety; route, reagent, and solvent selection; effect of water; in-process assays, controls, and specifications; practical considerations for scale-up; refining the process for simplicity and ruggedness; and troubleshooting, among other topics." --Reference and Research Book News, August 2012"I would hope that most readers of this journal are very familiar with the first edition of Neal Anderson's excellent book on Chemical Process Research and Development and are as keen to see the second edition as I was. The good news is that the new edition is bigger (by over 100 pages), better than the original, and cheaper... The big improvement in the new edition is the layout so that the schemes are now much closer to the relevant text than before which makes reading that much easier...Overall this book is highly recommended even if you already have a copy of the original edition." --Organic Process Research and Development
More details
Edition
2nd edition
Language
English
Place of publication
Oxford
United Kingdom
Publishing group
Elsevier Science & Technology
Target group
Professional and scholarly
Industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D.
Product notice
Paperback (trade)
Unsewn / adhesive bound
Dimensions
Height: 228 mm
Width: 154 mm
Thickness: 29 mm
Weight
787 gr
ISBN-13
978-1-4933-0125-6 (9781493301256)
Copyright in bibliographic data and cover images is held by Nielsen Book Services Limited or by the publishers or by their respective licensors: all rights reserved.
Schweitzer Classification
Other editions
New editions
Book
approx. 05/2026
3rd Edition
Academic Press
€146.50
Not yet published
Additional editions
Book
05/2012
2nd Edition
Academic Press
€111.42
Withdrawn from sale
E-Book
05/2012
2nd Edition
Academic Press
€94.95
Available for download
Previous edition
Neal G. Anderson
Practical Process Research & Development
Book
03/2000
Academic Press
€156.50
Article exhausted; check for reprint
Person
Neal G. Anderson is a synthetic organic chemist with over 40 years of experience in chemical process R&D in the pharmaceutical industry. He earned a B.S. degree in biology from the University of Illinois and a Ph.D. in medicinal chemistry from the University of Michigan, followed by industrial post-doctoral studies at McNeil Laboratories. He has extensive hands-on experience in the laboratory, pilot plant, and in manufacturing facilities. At Squibb / Bristol-Myers Squibb he made key contributions to processes for the manufacture of four major drug substances, including captopril, and has participated in 12 manufacturing start-ups and introductions of many processes to pilot plants. He received a BMS President's Award and spot awards, and his final position was Principal Scientist. In 1997, Anderson established Anderson's Process Solutions L.L.C., a consulting firm based in the USA to offer practical guidance on developing and implementing processes for bulk pharmaceuticals and fine chemicals. As part of these consulting services, he presents courses on selected aspects of practical process R&D. He is experienced in laboratory research, scale-up, and technology transfer to ensure reproducibility and optimal product quality.
Content
1. Introduction to the role of process development 2. Process safety3. Route selection 4. Reagent selection5. Solvent selection6. Effects of water7. In-process assays, in-process controls, and specifications8. Practical considerations for scale-up9. Optimizing processes by minimizing impurities10. Optimizing organometallic reactions 11. Workup12. Crystallization and purification13. Final product form and impurities14. Continuous operations 15. Refining the process for simplicity and ruggedness16. Process validation and implementation17. TroubleshootingGlossary and indices: general, reagents, reactions, and drug substances