Refractory Depression
Published on 1. February 1991
Book
Hardback
272 pages
978-0-88167-676-1 (ISBN)
Description
This focuses on endogenous depression that does not respond well to conventional pharmacological therapy or electroconvulsive therapy. More than 40 investigators present their findings and views on the nosology, classification, etiology and diagnosis of therapy-resistant depression and provide information on treatment strategies. The opening chapter offers insights on the clinical description and nosology of treatment-resistant depressions, based on a systematic evaluation of 300 patients. Attention is given to the clinical features and etiology of specific syndromes such as treatment-resistant manic-depressive disorder and rapid cycling bipolar disorder. Clinicians explore the role of polysomnography in evaluation of refractory depression and emphasize the importance of a trial of electroconvulsive therapy before a diagnosis of refractory depression is made. A review of principles of rational drug selection prepares the reader for the discussions of individual drugs and drug combinations.
A major portion of the book describes pharmacological therapies including fluoxetine enhancement of tricyclic antidepressants, combined treatment with imipramine and mianserine, combination therapy with monoamine oxidase inhibitors and tricyclic antidepressants, high-dose tranylcypromine, thyroid hormone potentiation of antidepressants, reserpine treatment, and narcotherapy. The contributors present definitive recommendations on use of anticonvulsants for lithium-refractory bipolar depressed patients and use of psychostimulants and lithium augmentation for refractory depression in elderly patients. The role of stereotactic cingulotomy in the treatment of intractable depression is also assessed.
This focuses on endogenous depression that does not respond well to conventional pharmacological therapy or electroconvulsive therapy. More than 40 investigators present their findings and views on the nosology, classification, etiology and diagnosis of therapy-resistant depression and provide information on treatment strategies. The opening chapter offers insights on the clinical description and nosology of treatment-resistant depressions, based on a systematic evaluation of 300 patients. Attention is given to the clinical features and etiology of specific syndromes such as treatment-resistant manic-depressive disorder and rapid cycling bipolar disorder. Clinicians explore the role of polysomnography in evaluation of refractory depression and emphasize the importance of a trial of electroconvulsive therapy before a diagnosis of refractory depression is made. A review of principles of rational drug selection prepares the reader for the discussions of individual drugs and drug combinations.
A major portion of the book describes pharmacological therapies including fluoxetine enhancement of tricyclic antidepressants, combined treatment with imipramine and mianserine, combination therapy with monoamine oxidase inhibitors and tricyclic antidepressants, high-dose tranylcypromine, thyroid hormone potentiation of antidepressants, reserpine treatment, and narcotherapy. The contributors present definitive recommendations on use of anticonvulsants for lithium-refractory bipolar depressed patients and use of psychostimulants and lithium augmentation for refractory depression in elderly patients. The role of stereotactic cingulotomy in the treatment of intractable depression is also assessed.
A major portion of the book describes pharmacological therapies including fluoxetine enhancement of tricyclic antidepressants, combined treatment with imipramine and mianserine, combination therapy with monoamine oxidase inhibitors and tricyclic antidepressants, high-dose tranylcypromine, thyroid hormone potentiation of antidepressants, reserpine treatment, and narcotherapy. The contributors present definitive recommendations on use of anticonvulsants for lithium-refractory bipolar depressed patients and use of psychostimulants and lithium augmentation for refractory depression in elderly patients. The role of stereotactic cingulotomy in the treatment of intractable depression is also assessed.
This focuses on endogenous depression that does not respond well to conventional pharmacological therapy or electroconvulsive therapy. More than 40 investigators present their findings and views on the nosology, classification, etiology and diagnosis of therapy-resistant depression and provide information on treatment strategies. The opening chapter offers insights on the clinical description and nosology of treatment-resistant depressions, based on a systematic evaluation of 300 patients. Attention is given to the clinical features and etiology of specific syndromes such as treatment-resistant manic-depressive disorder and rapid cycling bipolar disorder. Clinicians explore the role of polysomnography in evaluation of refractory depression and emphasize the importance of a trial of electroconvulsive therapy before a diagnosis of refractory depression is made. A review of principles of rational drug selection prepares the reader for the discussions of individual drugs and drug combinations.
A major portion of the book describes pharmacological therapies including fluoxetine enhancement of tricyclic antidepressants, combined treatment with imipramine and mianserine, combination therapy with monoamine oxidase inhibitors and tricyclic antidepressants, high-dose tranylcypromine, thyroid hormone potentiation of antidepressants, reserpine treatment, and narcotherapy. The contributors present definitive recommendations on use of anticonvulsants for lithium-refractory bipolar depressed patients and use of psychostimulants and lithium augmentation for refractory depression in elderly patients. The role of stereotactic cingulotomy in the treatment of intractable depression is also assessed.
More details
Series
Language
English
Place of publication
Philadelphia
United States
Target group
College/higher education
Professional and scholarly
Illustrations
36 line drawings, 2 half-tones
Dimensions
Height: 235 mm
Width: 155 mm
ISBN-13
978-0-88167-676-1 (9780881676761)
Copyright in bibliographic data is held by Nielsen Book Services Limited or its licensors: all rights reserved.
Schweitzer Classification
Content
Methodological considerations for the study of treatment-resistant depression, A.A.Nierenberg et al; the neurochemistry of refractory depression - a molecular view on therapy-resistant signal transfer, F.Sulser; current hypotheses of the mechanism of antidepressant treatments - implications for the treatment of refractory depression, D.S.Charney et al; potentiation of dopamine in the treatment of refractory depression, O.T.Osman and W.Z.Potter; refractory childhood depressive disorders from a pharmacotherapeutic perspective, N.E.Alessi; regional cerebral blood flow in refractory depression, S.Morinobu et al; a model for refractory depression - cerebral ventricular size and CSF transmitter metabolite concentrations in refractory depression, H.Standish-Barry; polysomnography in refractory depression, S.P.James et al; a trial of ECT is essential before a diagnosis of refractory depression is made, M.Fink; selectivity of antidepressants and resistant depression, S.A.Montgomery; fluoxetine enhancement of heterocyclic antidepressants, J.S.Rosenthal et al; rapid downregulation of cerebral beta-adrenoceptors by combined treatment with imipramine and mianserin, R.Klysner and A.Geisler; combined MAOI-TCA treatment in refractory depression, A.C.Pande et al; use of high dose tranylcypromine in resistant depression, J.D.Amsterdam; treatment-resistant bipolar affective disorder - phenomenological characteristics, pathophysiological mechanisms and novel therapies, R.L.Hauger et al; anticonvulsants as adjuncts or alternatives to lithium in refractory bipolar illness, R.M.Post; a review of psychostimulants in elderly patients with refractory depression, D.Gurevitch et al; lithium augmentation for refractory depression in old age, C.L.E.Katona and E.J.L.Finch; thyroid hormone potentiation of antidepressants, R.T.Joffe and W.Singer; rapid cycling bipolar disorder - clincal features, treatment and etiology, M.S.Bauer and P.C.Whybrow; oestrogen and refractory depression, B.B.Sherwin; reserpine augmentation in resistant depression - a review, J.Zohar et al; narcotherapy in resistant depressive patients, R.Karazman et al; the role of stereotactive cingulotomy in the treatment of intractable depression, A.J.Bouckoms.