Peptide-based Drug Design

Introduction: molecular biology of amino acid, peptide and oligopeptide transport, Rufus M. Williamson and Dale L. Oxender; peptide metabolism at brush-border membranes, Roger H. Erickson; peptide metabolism by gastric, pancreatic and lysosomal proteinases, Ramesh Krishnamoorthy and Ashim K. Mitra; biopharmaceutical properties and pharmacokinetics of peptide drugs, Hye J. Lee; intestinal peptide transport. Part 1 Intestinal absorption of B-lactam antibiotics, Akira Tsuji; oral absorption of angiotensin-converting enzyme inhibitors and peptide prodrugs, Shiyin Yee and Gordon L. Amidon; the intestinal oligopeptide transporter - molecular characterization and substrate specificity, Werner Kramer et al; oral delivery of therapeutic proteins and peptides by the B12-uptake system, Gregory J. Russell-Jones; prodrug approaches for improving peptidomimetic drug absorption, Barbra H. Stewart and Michael D. Taylor. Part 2 Liver peptide transport: hepatic processing of peptides, David L. Marks; approaches to modulating liver transport of peptide drugs, Mary L. Ruwart. Part 3 Blood-brain barrier peptide transport: blood-brain barrier peptide transport and peptide drug delivery to the brain, William M. Pardridge; oligopeptide drug delivery to the brain - importance of absorptive-mediated endocytosis and P-glycoprotein-associated active efflux transport at the blood-brain barrier, Tetsuya Terasaki and Akira Tsuji; molecular packaging - peptide delivery to the central nervous system by sequential metabolism, Nicholas Bodor and Laszlo Prokai. Part 4 Peptide transport in micro-organisms: bacterial peptide permeases as a drug delivery target, J. W. Payne; fungal peptide transport as a drug delivery system, Jeffrey M. Becker and Fred R. Naider. Part 5 Peptide metabolism: peptidomimetic design and chemistry approaches to peptide metabolism, T.K. Sawyer; peptide prodrugs designed to limit metabolism, Judi Moss; improving duration of action of peptide drugs, John J. Nestor Jr. Part 6 Methods and systems for evaluating transport and metabolism of peptide-based drugs - cell culture models for examining peptide absorption, Donald W. Miller et al; Elsbeth G. Chikale and Ronald T. Borchardt; gastrointestinal transport of peptides - experimental systems, David Fleisher; in vitro models of hepatic uptake - methods to determine kinetic parameters for receptor-mediated hepatic uptake, Yuichi Sugiyama and Yukio Kato.