Structure and Function of Plasma Proteins
Published on 26. March 2012
Book
Paperback/Softback
XX, 420 pages
978-1-4684-2681-6 (ISBN)
Description
1 Ontogeny of Human Plasma Proteins: Detection of the Onset and Site of Synthesis Using Genetic Markers and in Vitro Cultures.- 1.1. Introduction.- 1.2. Immunoglobulins.- 1.3. Complement.- 1.4. Haptoglobin System.- 1.5. Transferrins.- 1.6. ?-Lipoprotein Variants: The Ag and Lp Systems.- 1.7. Group-Specific Components: The Gc System.- 1.8. ?1-Antitrypsin: The Pi System.- 1.9. Ceruloplasmin.- 1.10. Other Adult Plasma Proteins.- 1.11. Fetal Proteins.- 1.12. ?-Fetoprotein (AFP).- 1.13. Carcinoembryonic Antigen.- 1.14. Fetal Sulfoglycoprotein Antigen (FSA).- 1.15. Other Fetal Proteins Associated with Cancer.- 1.16. Conclusion.- References.- 2 Transferrin.- 2.1. Introduction.- 2.2. Historical.- 2.3. Physicochemical Properties of Transferrin.- 2.4. The Metal-Binding Sites.- 2.5. Functions of Transferrin.- 2.6. Distribution and Metabolism.- 2.7. Conclusion.- References.- 3 Albumin Synthesis and Degradation.- 3.1. Introduction.- 3.2. Evolution and Variants.- 3.3. Albumin Metabolism.- 3.4. Albumin Transport.- 3.5. Development and Normal Values for Albumin Metabolism.- 3.6. Nutritional Control.- 3.7. Hormonal Effects.- 3.8. Osmotic Regulation.- 3.9. Environmental Effects.- 3.10. Degradation.- Addendum.- References.- 4 Turnover of Plasma Proteins.- 4.1. Introduction.- 4.2. Measurement of Protein Turnover.- 4.3. Mechanisms of Synthesis and Degradation of Liver-Produced Plasma Proteins.- 4.4. Regulation of Protein Turnover.- 4.5. Summary.- References.- 5 The Role of Sialic Acid in the Catabolism of Plasma Glycoproteins.- 5.1. Introduction.- 5.2. A Unified Mechanism for Turnover and Catabolism.- 5.3. Physiological Significance of Desialylation of Plasma Glycoproteins.- 5.4. Disorders of Glycoprotein Catabolism.- References.- 6 Catabolism of Plasma Proteins.- 6.1. Introduction.-6.2. Preparation of Labeled Proteins for Metabolic Studies.- 6.3. Some Considerations about Sites of Catabolism.- 6.4. Organs Involved in Plasma Protein Catabolism.- 6.5. Is the Catabolism of Plasma Proteins a One-Step Process?.- 6.6. Concluding Remarks.- References.- 7 Plasma Proteinase Inhibitors.- 7.1. Introduction.- 7.2. The Identification and Separation of Plasma Proteinase Inhibitors.- 7.3. ?1-Antichymotrypsin.- 7.4. ?1-Globulin Trypsin Inhibitor (?1-TI).- 7.5. ?2-Macroglobulin (?2-M).- 7.6. Inter-?-Trypsin Inhibitor (I?I).- 7.7. Antithrombin III (AT III).- 7.8. Cl-Esterase Inhibitor (Cl INH).- 7.9. Concluding Remarks.- Addendum.- References.- 8 Growth Regulation in Vitro and the Role of Serum.- 8.1. Introduction.- 8.2. Contact Inhibition of Locomotion and Density-Dependent Inhibition of Growth.- 8.3. Density-Dependent Inhibition of Growth and Serum Requirement.- 8.4. Transformation and the Loss of Contact Inhibition of Locomotion.- 8.5. Transformation and Serum Requirement.- 8.6. Transformation and Density-Dependent Inhibition of Growth.- 8.7. Density-Dependent Inhibition of Growth: Some Conclusions.- 8.8. Anchorage Dependence and Sensitivity to Polyanions of Normal and Transformed Cells.- 8.9. Fractionation of Serum.- 8.10. Physiological Action of Serum.- 8.11. Significance of Growth Regulation in Vitro.- References.- 9 Fractionation of Plasma Proteins.- 9.1. Introduction.- 9.2. Gel Chromatography.- 9.3. Ion Exchange Chromatography.- 9.4. Affinity Chromatography.- 9.5. Polyacrylamide Gel Electrophoresis.- 9.6. Isoelectric Focusing or Electrofocusing.- 9.7. Two-Dimensional Immunoelectrophoresis (Laurell Technique).- 9.8. Isotachophoresis.- 9.9. Two-Phase Separation Systems.- 9.10. Evidence of Denaturation.- Addendum.- References.- 10 Protein Chemistry ina General Hospital.- 10.1. Introduction.- 10.2. Methods of Protein Analysis-General Aspects.- 10.3. Chemical and Physical Methods for the Determination of Serum Proteins.- 10.4. Immunochemical Methods for the Measurement and Examination of Serum Proteins.- 10.5. Monoclonal Protein Increases.- 10.6. Plasma Proteins and Disease.- 10.7. Hypogammaglobulinemia.- 10.8. Hypergammaglobulinemia.- 10.9. Renal Disease.- 1
More details
Edition
Softcover reprint of the original 1st ed. 1976
Language
English
Place of publication
New York
United States
Target group
Professional and scholarly
Research
Illustrations
XX, 420 p.
Dimensions
Height: 229 mm
Width: 152 mm
Thickness: 24 mm
Weight
639 gr
ISBN-13
978-1-4684-2681-6 (9781468426816)
DOI
10.1007/978-1-4684-2679-3
Schweitzer Classification
Other editions
Additional editions
A. C. Allison
Structure and Function of Plasma Proteins
Book
09/1976
Kluwer Academic/Plenum Publishers
€109.13
Article exhausted; check different version
Content
1 Ontogeny of Human Plasma Proteins: Detection of the Onset and Site of Synthesis Using Genetic Markers and in Vitro Cultures.- 1.1. Introduction.- 1.2. Immunoglobulins.- 1.3. Complement.- 1.4. Haptoglobin System.- 1.5. Transferrins.- 1.6. ?-Lipoprotein Variants: The Ag and Lp Systems.- 1.7. Group-Specific Components: The Gc System.- 1.8. ?1-Antitrypsin: The Pi System.- 1.9. Ceruloplasmin.- 1.10. Other Adult Plasma Proteins.- 1.11. Fetal Proteins.- 1.12. ?-Fetoprotein (AFP).- 1.13. Carcinoembryonic Antigen.- 1.14. Fetal Sulfoglycoprotein Antigen (FSA).- 1.15. Other Fetal Proteins Associated with Cancer.- 1.16. Conclusion.- References.- 2 Transferrin.- 2.1. Introduction.- 2.2. Historical.- 2.3. Physicochemical Properties of Transferrin.- 2.4. The Metal-Binding Sites.- 2.5. Functions of Transferrin.- 2.6. Distribution and Metabolism.- 2.7. Conclusion.- References.- 3 Albumin Synthesis and Degradation.- 3.1. Introduction.- 3.2. Evolution and Variants.- 3.3. Albumin Metabolism.- 3.4. Albumin Transport.- 3.5. Development and Normal Values for Albumin Metabolism.- 3.6. Nutritional Control.- 3.7. Hormonal Effects.- 3.8. Osmotic Regulation.- 3.9. Environmental Effects.- 3.10. Degradation.- Addendum.- References.- 4 Turnover of Plasma Proteins.- 4.1. Introduction.- 4.2. Measurement of Protein Turnover.- 4.3. Mechanisms of Synthesis and Degradation of Liver-Produced Plasma Proteins.- 4.4. Regulation of Protein Turnover.- 4.5. Summary.- References.- 5 The Role of Sialic Acid in the Catabolism of Plasma Glycoproteins.- 5.1. Introduction.- 5.2. A Unified Mechanism for Turnover and Catabolism.- 5.3. Physiological Significance of Desialylation of Plasma Glycoproteins.- 5.4. Disorders of Glycoprotein Catabolism.- References.- 6 Catabolism of Plasma Proteins.- 6.1. Introduction.-6.2. Preparation of Labeled Proteins for Metabolic Studies.- 6.3. Some Considerations about Sites of Catabolism.- 6.4. Organs Involved in Plasma Protein Catabolism.- 6.5. Is the Catabolism of Plasma Proteins a One-Step Process?.- 6.6. Concluding Remarks.- References.- 7 Plasma Proteinase Inhibitors.- 7.1. Introduction.- 7.2. The Identification and Separation of Plasma Proteinase Inhibitors.- 7.3. ?1-Antichymotrypsin.- 7.4. ?1-Globulin Trypsin Inhibitor (?1-TI).- 7.5. ?2-Macroglobulin (?2-M).- 7.6. Inter-?-Trypsin Inhibitor (I?I).- 7.7. Antithrombin III (AT III).- 7.8. Cl-Esterase Inhibitor (Cl INH).- 7.9. Concluding Remarks.- Addendum.- References.- 8 Growth Regulation in Vitro and the Role of Serum.- 8.1. Introduction.- 8.2. Contact Inhibition of Locomotion and Density-Dependent Inhibition of Growth.- 8.3. Density-Dependent Inhibition of Growth and Serum Requirement.- 8.4. Transformation and the Loss of Contact Inhibition of Locomotion.- 8.5. Transformation and Serum Requirement.- 8.6. Transformation and Density-Dependent Inhibition of Growth.- 8.7. Density-Dependent Inhibition of Growth: Some Conclusions.- 8.8. Anchorage Dependence and Sensitivity to Polyanions of Normal and Transformed Cells.- 8.9. Fractionation of Serum.- 8.10. Physiological Action of Serum.- 8.11. Significance of Growth Regulation in Vitro.- References.- 9 Fractionation of Plasma Proteins.- 9.1. Introduction.- 9.2. Gel Chromatography.- 9.3. Ion Exchange Chromatography.- 9.4. Affinity Chromatography.- 9.5. Polyacrylamide Gel Electrophoresis.- 9.6. Isoelectric Focusing or Electrofocusing.- 9.7. Two-Dimensional Immunoelectrophoresis (Laurell Technique).- 9.8. Isotachophoresis.- 9.9. Two-Phase Separation Systems.- 9.10. Evidence of Denaturation.- Addendum.- References.- 10 Protein Chemistry ina General Hospital.- 10.1. Introduction.- 10.2. Methods of Protein Analysis-General Aspects.- 10.3. Chemical and Physical Methods for the Determination of Serum Proteins.- 10.4. Immunochemical Methods for the Measurement and Examination of Serum Proteins.- 10.5. Monoclonal Protein Increases.- 10.6. Plasma Proteins and Disease.- 10.7. Hypogammaglobulinemia.- 10.8. Hypergammaglobulinemia.- 10.9. Renal Disease.- 10.10. Central Nervous System.- 10.11. Gastrointestinal Disease.- 10.12. Liver Disease.- 10.13. Respiratory Disease.- 10.14. Skin Disease.- 10.15. Cardiovascular Disease.- 10.16. Pediatrics.- 10.17. Cryoproteinemia.- 10.18. Protein Changes in Association with Neoplasia.- References.