The Cancer Handbook

Part I The Molecular and Cellular Basis of Cancer Cell and Tissue Organization Stem Cells and Tumorigenesis Regulation of the Cell Cycle, Cell Cycle Checkpoints, and Cancer Apoptosis Genetic Susceptibility to Cancer The Role of Epigenetic Alterations in Cancer Genomic Instability and DNA Repair Micro-RNAs as Oncogenes and Tumour Suppressors Regulation of Translation in Malignant Transformation Human DNA Tumour Viruses RNA Tumour Viruses Invasion and Metastasis Angiogenesis The Biology of Tumour Stroma The Links between Inflammation and Cancer Telomerase Signalling by Steroid Receptors Signalling by Cytokines Signalling by Tyrosine Kinases Signaling by Ras and Rho GTPases Wnt Signal Transduction Transforming Growth Factor-ß And Cancer p53 Family Pathway in Cancer The Retinoblastoma Tumour Suppressor Development and Cancer- The HOX Gene Connection Part II The Causation and Prevention of Cancer Epidemiology in the Identification of Cancer Causes Mechanisms of Chemical Carcinogenesis The Formation of DNA Adducts Physical Causes of Cancer Non-genotoxic Causes of Cancer Infectious Agents and Cancer Short-Term Testing for Genotoxicity Cancer Bioassays Molecular Epidemiology of Cancer and the Use of Biomarkers Dietary Genotoxins and Cancer Tobacco Use and Cancer Occupational Causes of Cancer Intervention and Chemoprevention of Cancer - Treatment of Carcinogenesis Part III Systematic Oncology Introduction to the Diagnosis of Cancer Skin Oral Cavity and Major and Minor Salivary Glands Respiratory System Upper Gastrointestinal Tract Lower Gastrointestinal Tract Pancreas Liver, Gallbladder, and Extrahepatic Bile Ducts Endocrine Organs Breast Female Reproductive System Urinary Tract Male Genital Tract Lymph Nodes Blood and Bone Marrow: Myeloid Leukaemias and Related Neoplasms Bones Soft Tissues Pleura and Peritoneum Heart Neuromuscular System Eye and Ocular Adnexa Ear Unknown Primary Part IV Pre-clinical models for Human Cancer Advantages and Limitations of Models for Cancer and Malignant Cell Progression Basic Tissue and Cell Culture in Cancer Research Transgenic Technology in the Study of Oncogenes and Tumour-Suppressor Genes Genetic Models: A Powerful Technology for the Study of Cancer Gene Knockouts in Cancer Research Human Tumours in Animal Hosts Mathematical Models of Cancer Growth and Development Models for Tumour Growth and Differentiation Models for Tumour Cell-Stromal Cell Interactions Models for Angiogenesis Models for Tumour Cell Adhesion and Invasion Models for Tumour Cell-Endothelial Cell Interactions Models for Tumour Metastasis Models for Drug Development and Drug Resistance Models for Immunotherapy and Cancer Vaccines Models for Gene Therapy Models for Breast Cancers Models for Prostate Cancer Models for Genitourinary Cancer - Hereditary Renal Carcinogenesis Mouse Models for Gastrointestinal Carcinomas Models for Liver Cancer Models for Lymphoma Models for Human Leukaemias Models for Sarcomas Models for Skin Cancer Models for CNS Malignancies Part V The Treatment of Cancer Conventional Chemotherapeutics Rational Drug Design of Small Molecule Anticancer Agents: Preclinical Discovery Rational Drug Design of Small Molecule Anticancer Agents: Early Clinical Development Modern Approaches to Radiation Therapy Gene and Viral Therapy Cancer Vaccines Antibody Therapy for Cancer Anti-angiogenic and Anti-stromal Therapy RNA Interference Cancer Chemoprevention Mechanisms and Management of Cancer Pain Clinical Trial Design for Anticancer Therapies Head and Neck Cancer Melanoma Antihormonal Therapy for Breast and Prostate Cancer Collaborative Approach to Multidisciplinary Breast Cancer Care Management of Haematological Malignancies Multidisciplinary Team Management of Lung Cancer Multidisciplinary Team Management of Gynaecological Cancers Multidisciplinary Management of Genitourinary Malignancies Multidisciplinary Team Management of Upper Gastrointestinal, Hepatic, Pancreatic, and Biliary Cancers ...of Colorectal Cancer.