Animal Cell Culture

Preface.- 1 Cell line development.- 2 Transient recombinant protein expression in mammalian cells.- 3 Hybridoma technology for the in vitro production of therapeutic antibodies.- 4 Bioreactors for mammalian cells.- 5 Mass Transfer and Mixing Across the Scales in Animal Cell Culture.- 6 Hydrodynamic Damage to Animal Cells.- 7 Monitoring of cell culture.- 8 Serum and protein free media.- 9 Glycosylation in Cell Culture.- 10 Modelling of mammalian cell cultures.- 11 Mammalian Cell Line Selection Strategies for High-Producers.- 12 Building a Cell Culture Process with Stable Foundations: Searching for Certainty in an Uncertain World.- 13 Perfusion Processes.- 14 Single-use bioreactors for animal and human cells.- 15 An Overview of Cell Culture Engineering for the Insect Cell-Baculovirus Expression Vector System (BEVS).- 16 Metabolic flux analysis: a powerful tool in animal cell culture.- 17 Cell immobilization for the production of viral vaccines.- 18 Cell Engineering for Therapeutic Protein Production.- 19 Proteomics in Cell Culture: From genomics to combined 'omics for cell line engineering and bioprocess development.- 20 Metabolomics in animal cell culture.- 21 Process Analytical Technology and Quality-by-Design for Animal Cell Culture.- 22 Biosafety recommendations on the handling of animal cell cultures.- 23 Biopharmaceutical products from animal cell culture.- Index