Calcium Channel Modulators in Heart and Smooth Muscle
Basic Mechanisms and Pharmacological Aspects. Proceedings of the 33rd Oholo Conference, Eilat, Israel 1989
Published on 18. December 1990
Book
Hardback
XII, 396 pages
978-3-527-28251-7 (ISBN)
Description
The contributions are selected from lectures given at the 33rd OHOLO conference in Eilat, Israel, 1989. World leading experts inform about the present knowledge of basic mechanisms involved in the modulation of calcium channels. All the articles treat the subject in respect to biochemical, molecular biological or pharmacological aspects; clinical studies are not included. The book is aimed at biochemists, molecular biologists, pharmacologists or medicinal chemists in basic research or industry (especially pharmaceuticals).
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Content
Introduction: calcium - the control of a charismatic cation, D.J.Triggle. Part 1 Receptor-operated and voltage-dependent mechanisms: on the structure of calcium channels - the oligochannel concept, H.Schindler; possible role for phospholipase C in potentiation of neurotransmitter release - "invitro" assay for synaptic facilitation, D.Atlas, et al; fingerprinting of ligand mediated cellular activation - relationships between inositol phosphates, phosphatidylinositols, intracellular calcium and cell function, P.Taylor, et al; receptor-operated calcium channels in vascular smooth muscle - from physiology to pharmacology, U.T.Ruegg, et al; temporal integration of receptor responses in BC3H-1 muscle cells, R.D.Brown, et al; calcium utilization of z-adrenoceptors, P.BTimmermans; relationship between catecholamine secretion and disinct calcium fluxes in cultured medullary chromafin cells, E.Heldman, et al; angiotensin 11 stimulates catecholamine release in cultured bovine adrenomedullary cells through a cytosolic calcium dependent mechanism, R.Zimlichman, et al; quantitative determination of prazosin in plasma using specific antibodies, G.Amitai, et al; purification and labelling of the a1 adrenergic receptor, J.F.Reece, et al; modulation of cardiac sodium channel by brevetoxin-3, G.Jeglitsch, et al. Part 2 Excitation-contraction coupling in heart and smooth muscle: inhibition of sarcoplasmic reticular Ca release in canine ventricular muscle by the Ca channel agonist, Bay K8644 - are sarcolemmal Ca channels involved?, D.Bose, et al; antigen-stimulated phosphorylation of myosin and histamine secretion from RBL-2H3 cells, I.Peleg, et al; calcium homeostasis in vascular tissues, C.Frelin, et al; short and long term effects of antiarrhythmic drugs on cultured cardiomycytes, G.Kessler-Icekson, et al. Part 3 Pharmacodynamic effects of calcium channel modulators and related endogeneous factors: growth and metabolism of cultured vascular smooth muscle cells in hypertension, T.J.Resink, et al; calcium antagonists and myocardial protection during ischemia and reperfusion - the St.Thomas experience, M.Avkiran, et al; platelet activating factor (PAF) in cardiac and coronary pathophysiology, G.Feuerstein; interactions between voltage-dependent calcium channels and peripheral benzodiazepine receptor lignads in the heart, G.T.Bolger, et al; characterization of partially purified peripheral benzodiazepine binding inhibitor from human cerebrospinal fluid (CSF) - its arhythomogenic effects in the rat, Y.Katz; the effects of nitrovasodialators on peripheral benzodiazepine receptors in the guinea pig heart, B.A.Weissman, et al; cardiovascular effects of mammalian endothelines and snake venom sarafotoxins, Z.Wollberg, et al; gingival hyperplasia induced by calcium channel blockers, A.Zlotogorski, et al.