Macromolecules Containing Metal and Metal-Like Elements

Preface Series Preface 1. Organometallic Compounds in Biomedical Applications (Charles E. Carraher Jr. and Charles U. Pittman Jr.) I. Introduction II. Case for Metal-Containing Bioactive Agents A. Tin-Containing Biocidal Polymers B. Ferrocene: A Therapeutic Role in Polymeric Systems? C. Polymeric Moderation of OsO4 Toxicity III. Miscellaneous Polymers A. Metal Chelation Polymers B. Condensation Polymers IV. Small-Molecule Analogs V. Summary VI. References 2. Metal-Labeled DNA on Surfaces (Heinz-Bernhard Kraatz, Yitao Long, and Todd C. Sutherland) I. Introduction II. Ferrocene Nucleotides III. Ferrocene-DNA Conjugates IV. Other Metal-DNA Conjugates V. Metallated DNA A. Cu-DNA B. M-DNA VI. Summary VII. Acknowledgments VIII. References 3. Artificial DNA through Metal-Mediated Base Pairing: Structural Control and Discrete Metal Assembly (Mitsuhiko Shionoya) I. Introduction II. Alternative Hydrogen-Bonding Schemes for DNA Base Pairing III. Non-Hydrogen-Bonding Basepairs in DNA IV. Metal-Mediated Base Pairing in DNA A. Basic Concept B. Artificial Nucleosides Designed for Metal-Mediated Base Pairs C. Incorporation of a Metallo-Base Pair in DNA and Its Effect on Thermal Stability D. Discrete Self-Assembled Metal Arrays in DNA V. Future Prospects for Artificial Metallo-DNA VI. Summary VII. References 4. Organotin Macromolecules as Anticancer Drugs (Charles E. Carraher Jr. and Deborah Siegmann-Louda) I. General II. Anticancer Activity of Small Organotin Compounds III. Molecule-Level Studies on Monomeric Organotin Compounds IV. Anticancer Activity of Organotin Polymers V. Future Work VI. References 5. Organotin Oligomeric Drugs Containing the Antivirial Agent Acyclovir (Charles E. Carraher Jr. and Robert E. Bleicher) I. Early History of Organotin Compounds II. Mechanisms and Reactions III. General Structures IV. Acyclovir V. Bioactivity of Related Compounds VI. Experimental Work VII. Results and Discussion VIII. References 6. Polymeric Ferrocene Conjugates as Antiproliferative Agents (Eberhard W. Neuse) I. Introduction II. The Ferrocene-Ferricenium System in the Biological Environment III. Polymer-Drug Conjugation as a Pharmaceutical Tool for Drug Delivery IV. Polymer-Ferrocene Conjugates: Synthesis and Structure A. The Carrier Component: Structural Considerations B. Conjugates of Amide-Linked Ferrocene C. Conjugates of Ester-Linked Ferrocene V. Bioactivity Screening VI. Summary and Conclusions VII. Acknowledgments VIII.References 7. Polymeric Platinum-Containing Drugs in the Treatment of Cancer (Deborah W. Siegmann-Louda and Charles E. Carraher Jr) I. Introduction II. Basic Mechanisms of Pt(II) Complex Formation III. Nomenclature IV. Currently Approved Platinum-Containing Compounds V. Properties of Cisplatin VI. Structure-Activity Relationships VII. Polymer-Drug Conjugation Strategy and Possible Benefits A. Polymers as Carriers B. Polymers as Drugs C. General VIII. Mainchain-Incorporated cis-Diamine-Coordinated Platinum A. Simple Amine Derivatives B. Amino Acid Derivatives C. Other Nitrogen-Platinum Products D. Solution Stability E. Thermal Stability F. Antiviral Activity IX. Platinum Carrier-Bound Complexes via Nitrogen Donor Ligands A. Pt-Polyphosphazenes B. Slowly Biofissionable PtN Complexes Anchored through Primary and Secondary Amines C. Biofissionable PtN Complexes Anchored through Primary and Secondary Amines X. Pt-O-Bound Polymers XI. Mixed Pt-O/Pt-N-Bound Polymers XII. Future Work XIII. Acknowledgments XIV. References 8. New Organic Polyacid-Inorganic Compounds for Improved Dental Materials (Bill M. Culbertson, Minhhoa H. Dotrong, and Scott R. Schricker) I. Introduction II. Glass Ionomer Technology A. Amino Acid-Modified Glass Ionomers B. N-Vinylpyrrolidone (NVP)-Modified Glass Ionomers III. New NVP-Modified Glass Ionomers: Experimental Work A. Materials B. Polymer Synthesis C. Characterization D. Physical Properties IV. Results and Discussion V. Conclusions VI. References Index.